Evidence map›Paper›PMID 29535413›Full record

ArticleScientific reports2018

Tailoring light delivery for optogenetics by modal demultiplexing in tapered optical fibers.

Marco Pisanello, Filippo Pisano, Leonardo Sileo, Emanuela Maglie, Elisa Bellistri, Barbara Spagnolo, Gil Mandelbaum, Bernardo L Sabatini, Massimo De Vittorio, Ferruccio Pisanello

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 83 citations in OpenAlex.

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  13. An opponent striatal circuit for distributional reinforcement learning.bioRxiv : the preprint server for biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Marco PisanelloIstituto Italiano di Tecnologia (IIT), Center for Biomolecular Nanotechnologies, 73010, Arnesano (LE), Italy.
Filippo PisanoIstituto Italiano di Tecnologia (IIT), Center for Biomolecular Nanotechnologies, 73010, Arnesano (LE), Italy.
Leonardo SileoIstituto Italiano di Tecnologia (IIT), Center for Biomolecular Nanotechnologies, 73010, Arnesano (LE), Italy.
Emanuela MaglieIstituto Italiano di Tecnologia (IIT), Center for Biomolecular Nanotechnologies, 73010, Arnesano (LE), Italy.
Elisa BellistriIstituto Italiano di Tecnologia (IIT), Center for Biomolecular Nanotechnologies, 73010, Arnesano (LE), Italy.
Barbara SpagnoloIstituto Italiano di Tecnologia (IIT), Center for Biomolecular Nanotechnologies, 73010, Arnesano (LE), Italy.
Gil MandelbaumDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, 02115 MA, USA.
Bernardo L SabatiniDepartment of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, 02115 MA, USA.ORCID 0000-0003-0095-9177
Massimo De VittorioIstituto Italiano di Tecnologia (IIT), Center for Biomolecular Nanotechnologies, 73010, Arnesano (LE), Italy.
Ferruccio PisanelloIstituto Italiano di Tecnologia (IIT), Center for Biomolecular Nanotechnologies, 73010, Arnesano (LE), Italy. ferruccio.pisanello@iit.it.ORCID 0000-0002-1489-7758
Italian Institute of Technology · ITUniversity of Salento · ITHoward Hughes Medical Institute · US

Funding

Controlling the spatial extent of light-based monitoring and manipulation of neural activity in vivoUF1NS108177 · NINDS · HARVARD MEDICAL SCHOOL · PI ASSAD, JOHN, DEVITTORIO, MASSIMO · 2018 to 2018
$1.9M
Novel optrodes for large-scale electrophysiology and site-specific stimulationU01NS094190 · NINDS · HARVARD MEDICAL SCHOOL · PI ASSAD, JOHN, BERDONDINI, LUCA · 2015 to 2017
$1.6M
NINDS NIH HHS U01 NS094190NINDS NIH HHS UF1 NS108177
6 · The paper itself

Abstract

Optogenetic control of neural activity in deep brain regions ideally requires precise and flexible light delivery with non-invasive devices. To this end, Tapered Optical Fibers (TFs) represent a versatile tool that can deliver light over either large brain volumes or spatially confined sub-regions, while being sensibly smaller than flat-cleaved optical fibers. In this work, we report on the possibility of further extending light emission length along the taper in the range 0.4 mm-3.0 mm by increasing the numerical aperture of the TFs to NA = 0.66. We investigated the dependence between the input angle of light (θ

Indexed as

AnimalsHumansMaleOptical FibersOptogeneticsPhotic StimulationVisual Cortex

Identifiers

PMID29535413
PMCPMC5849750
OpenAlexW2794631010

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.