Evidence map›Paper›PMID 29535398›Full record

ArticleScientific reports2018

Trichostatin A inhibits the activation of Hepatic stellate cells by Increasing C/EBP-α Acetylation in vivo and in vitro.

Di Ding, Lin-Lin Chen, Ying-Zhen Zhai, Chen-Jian Hou, Li-Li Tao, Shu-Han Lu, Jian Wu, Xiu-Ping Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 29 citations in OpenAlex.

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  13. Therapeutic molecular targets of SSc-ILD.Journal of scleroderma and related disorders · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Di DingDepartment of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Lin-Lin ChenDepartment of Pathology, The Fifth People's Hospital, Fudan University, Shanghai, 200040, China.
Ying-Zhen ZhaiDepartment of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Chen-Jian HouDepartment of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Li-Li TaoDepartment of Pathology, Peking University, Shenzhen Hospital, Shenzhen, 518036, China.
Shu-Han LuDepartment of Nutrition, University of California at Davis, Davis, California, USA.
Jian WuDepartment of Medical Microbiology, Key Laboratory of Molecular Virology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. jian.wu@fudan.edu.cn.ORCID 0000-0001-9933-7364
Xiu-Ping LiuDepartment of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China. xpliu1228@fudan.edu.cn.
Shanghai Medical College of Fudan University · CNFudan University · CNPeking University Shenzhen Hospital · CNUniversity of California, Davis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reversal of activated hepatic stellate cells (HSCs) to a quiescent state and apoptosis of activated HSCs are key elements in the reversion of hepatic fibrosis. CCAAT/enhancer binding protein α (C/EBP-α) has been shown to inhibit HSC activation and promote its apoptosis. This study aims to investigate how C/EBP-α acetylation affects the fate of activated HSCs. Effects of a histone deacetylation inhibitor trichostatin A (TSA) on HSC activation were evaluated in a mouse model of liver fibrosis caused by carbon tetrachloride (CCl

Indexed as

AcetylationAnimalsApoptosisBinding SitesBiomarkersCarbon TetrachlorideCCAAT-Enhancer-Binding Protein-alphaCell LineGene ExpressionHepatic Stellate CellsHumansHydroxamic AcidsImmunohistochemistryLiver CirrhosisMaleMiceBiomarkersCarbon TetrachlorideCCAAT-Enhancer-Binding Protein-alphaHydroxamic Acidstrichostatin A

Identifiers

PMID29535398
PMCPMC5849734
OpenAlexW2794007086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.