SynthesisScientific reports2018
Bioimpedance-defined overhydration predicts survival in end stage kidney failure (ESKF): systematic review and subgroup meta-analysis.
Synthesis in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 4 syntheses or guidelines pooled it, 122 citations in OpenAlex.
- Lean tissue mass is associated with adverse outcomes across different stages of chronic kidney disease: a systematic review and meta-analysis.Scientific reports · 2026Pooled it
- Bioimpedance Indices of Fluid Overload and Cardiorenal Outcomes in Heart Failure and Chronic Kidney Disease: a Systematic Review.Journal of cardiac failure · 2022Pooled it
- Effect of bioimpedance-defined overhydration parameters on mortality and cardiovascular events in patients undergoing dialysis: a systematic review and meta-analysis.The Journal of international medical research · 2021Pooled it
- I Brazilian guideline on hypertension in dialysis of the Brazilian Society of Nephrology.Jornal brasileiro de nefrologiaGuideline
- Cost-effectiveness of bioimpedance-guided fluid management in patients undergoing haemodialysis: the BISTRO RCT.Health technology assessment (Winchester, England) · 2025Trial
- Effect of oral nutritional supplementation combined with impedance vectors for dry weight adjustment on the nutritional status, hydration status and quality of life in patients on chronic hemodialysis: A pilot study.Clinical nutrition ESPEN · 2023Trial
- The effect of BCM guided dry weight assessment on short-term survival in Chinese hemodialysis patients : Primary results of a randomized trial - BOdy COmposition MOnitor (BOCOMO) study.BMC nephrology · 2020Trial
- Fluid overload modifies ambulatory blood pressure and pulse wave characteristics in hemodialysis patients undergoing targeted fluid management.Clinical kidney journal · 2026Article
- Multimodal Diagnostic Ultrasound for Congestion, Perfusion, and Ultrafiltration Tolerance in Maintenance Hemodialysis: A Narrative Review.Diagnostics (Basel, Switzerland) · 2026Review
- Bioelectrical Impedance in Pediatric Dialysis: Clinical Applications, Limitations, and Opportunities.Hemodialysis international. International Symposium on Home Hemodialysis · 2026Review
- Muscle loss must be interpreted in the context of fluid imbalance: a dual-parameter model predicts functional outcomes after acute stroke.European geriatric medicine · 2026Article
- Associations of Biomarkers and Body Water with Dengue Status and Length of Hospital Stay: A Single-Center Observational Study.Pathogens (Basel, Switzerland) · 2026Observational
- The Dry-Weight Dilemma: Survey Results Based on a Qualitative Interview Study on Fluid Overload in Hemodialysis.Kidney medicine · 2026Article
- Subclinical overhydration predicts lower time in range and greater glycemic variability in type 2 diabetes on hemodialysis.Scientific reports · 2026Article
- Management Strategies for Congestive Heart Failure in Chronic Kidney Disease: Narrative Review.Biomedicines · 2026Review
- Vulnerability and short clinical outcomes in patients on the deceased-donor kidney transplant waiting list.Clinical and experimental nephrology · 2026Article
- Management of Hypertension in Patients Undergoing Peritoneal Dialysis: A Narrative Review.Cureus · 2026Review
- Assistive Technologies to Guide the Management of Volume Overload in Hemodialysis Patients: Are They Ready for Implementation in Daily Clinical Practice?Life (Basel, Switzerland) · 2026Article
- Fluid Management Based on Bioimpedance, Blood Volume, and Patient Reports: A Quality Improvement Project in Maintenance Hemodialysis.Kidney medicine · 2026Article
- Optimizing hemodialysis management using bioelectrical impedance analysis: emphasizing the significance of the phase angle.Renal failure · 2025Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Both overhydration and comorbidity predict mortality in end-stage kidney failure (ESKF) but it is not clear whether these are independent of one another. We undertook a systematic review of studies reporting outcomes in adult dialysis patients in which comorbidity and overhydration, quantified by whole body bioimpedance (BI), were reported. PubMed, EMBASE, PsychInfo and the Cochrane trial database were searched (1990-2017). Independent reviewers appraised studies including methodological quality (assessed using QUIPS). Primary outcome was mortality, with secondary outcomes including hospitalisation and cardiovascular events. Of 4028 citations identified, 46 matched inclusion criteria (42 cohorts; 60790 patients; 8187 deaths; 95% haemodialysis/5% peritoneal dialysis). BI measures included phase angle/BI vector (41%), overhydration index (39%) and extra:intracellular water ratio (20%). 38 of 42 cohorts had multivariable survival analyses (MVSA) adjusting for age (92%), gender (66%), diabetes (63%), albumin (58%), inflammation (CRP/IL6-37%), non-BI nutritional markers (24%) and echocardiographic data (8%). BI-defined overhydration (BI-OH) independently predicted mortality in 32 observational cohorts. Meta-analysis revealed overhydration >15% (HR 2.28, 95% CI 1.56-3.34, P < 0.001) and a 1-degree decrease in phase angle (HR 1.74, 95% CI 1.37-2.21, P < 0.001) predicted mortality. BI-OH predicts mortality in dialysis patients independent of the influence of comorbidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.