Evidence map›Paper›PMID 29535219›Full record

ArticleCancer research2018

Visualization of Breast Cancer Metabolism Using Multimodal Nonlinear Optical Microscopy of Cellular Lipids and Redox State.

Jue Hou, Joshua Williams, Elliot L Botvinick, Eric O Potma, Bruce J Tromberg

Abstract read
In one paragraph

Article in Cancer research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Glycosylated protein-related microenvironmental features in breast cancer are associated with patient prognosis.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Article
  3. Article
  4. Label-Free Optical Metabolic Imaging in Cells and Tissues.Annual review of biomedical engineering · 2023
    Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Ultrasound-Enhanced Chemiluminescence for Bioimaging.Frontiers in bioengineering and biotechnology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jue HouLaser Microbeam and Medical Program (LAMMP), Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California.
Joshua WilliamsLaser Microbeam and Medical Program (LAMMP), Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California.
Elliot L BotvinickLaser Microbeam and Medical Program (LAMMP), Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California.
Eric O PotmaLaser Microbeam and Medical Program (LAMMP), Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California.
Bruce J TrombergLaser Microbeam and Medical Program (LAMMP), Beckman Laser Institute and Medical Clinic, University of California Irvine, Irvine, California. bjtrombe@uci.edu.
Beckman Laser Institute and Medical Clinic · USUniversity of California, Irvine · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI BOTVINICK, ELLIOT LAWRENCE · 2012 to 2017
$7.0M
Developing DOSI Technology for Monitoring Response To Breast Cancer ChemotherapyR01CA142989 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI DURKIN, ANTHONY J · 2010 to 2017
$4.1M
Quantitative multiphoton microscopy for non-invasive diagnosis of melanomaR01CA195466 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI BALU, MIHAELA, KELLY, KRISTEN M · 2016 to 2018
$825k
NCATS NIH HHS UL1 TR001414NCI NIH HHS P30 CA062203NCI NIH HHS R01 CA142989NCI NIH HHS R01 CA195466NIBIB NIH HHS P41 EB015890
6 · The paper itself

Abstract

Label-free nonlinear optical microscopy (NLOM) based on two-photon excited fluorescence (TPEF) from cofactors nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD

Indexed as

Breast NeoplasmsCollagenEpithelial CellsEstradiolExtracellular MatrixFemaleFlavin-Adenine DinucleotideGlucoseGlycolysisHumansLipid MetabolismLipidsNADNonlinear Optical MicroscopyOxidation-ReductionSpheroids, CellularCollagenEstradiolFlavin-Adenine DinucleotideGlucoseLipidsNAD

Identifiers

PMID29535219
PMCPMC5955854
OpenAlexW2792962547

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.