Evidence map›Paper›PMID 29535198›Full record

ArticlemBio2018

Antigenic Variation in

M Georgieva, L Kagedan, Ying-Jie Lu, C M Thompson, M Lipsitch

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

  1. Trial
  2. Identification ofJournal of proteome research · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Diverse Mechanisms of Protective Anti-Pneumococcal Antibodies.Frontiers in cellular and infection microbiology · 2022
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Conformation of the Solute-Binding Protein AdcAII Influences Zinc Uptake inFrontiers in cellular and infection microbiology · 2021
    Article
  14. Article
  15. Article
  16. Review
  17. Sugar-Coated Killer: Serotype 3 Pneumococcal Disease.Frontiers in cellular and infection microbiology · 2020
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

M GeorgievaCenter for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA georgiev@hsph.harvard.edu.ORCID 0000-0002-4553-7894
L KagedanCenter for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Ying-Jie LuDivision of Infectious Diseases, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
C M ThompsonCenter for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
M LipsitchCenter for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.ORCID 0000-0003-1504-9213
Center for Disease Dynamics, Economics & Policy · USBoston Children's Hospital · US

Funding

VACCINATION AND THE EVOLUTIONARY DYNAMICS OF PNEUMOCOCCIR01AI048935 · NIAID · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LIPSITCH, MARC · 2001 to 2016
$8.8M
NIAID NIH HHS R01 AI048935
6 · The paper itself

Abstract

Genomic analysis reveals extensive sequence variation and hot spots of recombination in surface proteins of

Indexed as

Antigenic VariationImmune EvasionAntibodies, BacterialBacterial ProteinsBlood Bactericidal ActivityComplement Factor HHumansPhagocytosisPneumococcal InfectionsProtein BindingStreptococcus pneumoniaeAntibodies, BacterialBacterial ProteinsComplement Factor HSpsA protein, Streptococcus pneumoniaeantigenic variationPspCStreptococcus pneumoniae

Identifiers

PMID29535198
PMCPMC5850329
OpenAlexW2789538147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.