ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2018
Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration.
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In one paragraph
Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
4.4field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- Lactate Promotes Liver Regeneration by Increasing Fatty Acid Oxidation Through GCN5-Mediated H3K9 Lactylation.Cellular and molecular gastroenterology and hepatology · 2026Article
- Hydrogen gas with hypothermic machine perfusion induces lipidomic alterations in donation-after-cardiac-death rat livers.Journal of lipid research · 2026Article
- L-Theanine Ameliorates Obesity-Related Complications Induced by High-Fat Diet in Mice: Insights from Transcriptomics and Metabolomics.Foods (Basel, Switzerland) · 2024Article
- The Role of Mechanistic Biomarkers in Understanding Acetaminophen Hepatotoxicity in Humans.Drug metabolism and disposition: the biological fate of chemicals · 2024Review
- Dynamic changes in the mouse hepatic lipidome following warm ischemia reperfusion injury.Scientific reports · 2024Article
- Article
- Inhibition of p53 Sulfoconjugation Prevents Oxidative Hepatotoxicity and Acute Liver Failure.Gastroenterology · 2022Article
- Preclinical models of idiosyncratic drug-induced liver injury (iDILI): Moving towards prediction.Acta pharmaceutica Sinica. B · 2021Review
- Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk.Acta pharmaceutica Sinica. B · 2021Article
- Biomarkers of drug-induced liver injury: a mechanistic perspective through acetaminophen hepatotoxicity.Expert review of gastroenterology & hepatology · 2021Review
- Mitochondrial Membrane Potential Drives Early Change in Mitochondrial Morphology After Acetaminophen Exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- The development and hepatotoxicity of acetaminophen: reviewing over a century of progress.Drug metabolism reviews · 2020Review
- Regulation of Signaling and Metabolism by Lipin-mediated Phosphatidic Acid Phosphohydrolase Activity.Biomolecules · 2020Review
- Lack of Multidrug Resistance-associated Protein 4 Prolongs Partial Hepatectomy-induced Hepatic Steatosis.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Metabolomics of Aurantio-Obtusin-Induced Hepatotoxicity in Rats for Discovery of Potential Biomarkers.Molecules (Basel, Switzerland) · 2019Article
- A phospholipase D2 inhibitor, CAY10594, ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis.Scientific reports · 2019Article
- Animal models of drug-induced liver injury.Biochimica et biophysica acta. Molecular basis of disease · 2019Review
- The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2019Article
- Biomarkers of drug-induced liver injury.Advances in pharmacology (San Diego, Calif.) · 2019Review
- Mechanisms and biomarkers of liver regeneration after drug-induced liver injury.Advances in pharmacology (San Diego, Calif.) · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Andrew J LutkewitteDiv. of Geriatrics and Nutritional Sciences, Dept. of Medicine, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: alutkew@wustl.edu.
George G SchweitzerDiv. of Geriatrics and Nutritional Sciences, Dept. of Medicine, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: george.schweitzer@wustl.edu.
Stefanie Kennon-McGillDept. of Environmental and Occupational Health, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address: skennonmcgill@uams.edu.
Melissa M ClemensInterdisciplinary Biomedical Sciences Graduate Program, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Laura P JamesDept. of Pediatrics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address: jameslaurap@uams.edu.
Hartmut JaeschkeDept. of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA. Electronic address: hjaeschke@kumc.edu.
Brian N FinckDiv. of Geriatrics and Nutritional Sciences, Dept. of Medicine, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: bfinck@wustl.edu.
Mitchell R McGillDept. of Environmental and Occupational Health, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA. Electronic address: mmcgill@uams.edu.
University of Arkansas for Medical Sciences · USWashington University in St. Louis · USUniversity of Arkansas Medical Center · USUniversity of Kansas Medical Center · US
Funding
WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MWashington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8MWashington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MPRINCIPLES IN CARDIVASCULAR RESEARCH TRAINING PROGRAMT32HL007081 · NHLBI · WASHINGTON UNIVERSITY · PI Abhinav Diwan, Karen Ellen Joynt Maddox · 1985 to 2026
$10.6MPediatric Gastroenterology Research Training ProgramT32DK077653 · NIDDK · WASHINGTON UNIVERSITY · PI PHILLIP I TARR · 2007 to 2026
$5.8MLIPIN 1 IN THE REGULATION OF HEPATIC LIPID METABOLISMR01DK078187 · NIDDK · WASHINGTON UNIVERSITY · PI FINCK, BRIAN N · 2008 to 2016
$2.8MLIPIN 1 AND CARDIAC METABOLISM IN THE CONTEXT OF LIPID OVERLOADR01HL119225 · NHLBI · WASHINGTON UNIVERSITY · PI FINCK, BRIAN N · 2014 to 2017
$1.5MNCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NHLBI NIH HHS R01 HL119225NHLBI NIH HHS T32 HL007081NIDDK NIH HHS P30 DK052574NIDDK NIH HHS P30 DK056341NIDDK NIH HHS R01 DK078187NIDDK NIH HHS T32 DK077653
Abstract
PubMed holds no abstract for this paper.
Indexed as
Liver RegenerationAcetaminophenAdultAgedAged, 80 and overAnimalsChemical and Drug Induced Liver InjuryDrug OverdoseFemaleHumansLiverMaleMiceMice, Inbred C57BLMiddle AgedNuclear ProteinsAcetaminophenLipin 2 protein, mouseLpin1 protein, mouseNuclear ProteinsPhosphatidate PhosphatasePhosphatidic AcidsTOR Serine-Threonine Kinases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.