Evidence map›Paper›PMID 29534937›Full record

ArticleBioorganic & medicinal chemistry2018

Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation.

Zhengyuan Zhou, Satish K Chitneni, Nick Devoogdt, Michael R Zalutsky, Ganesan Vaidyanathan

Open access · bronzeAbstract read
In one paragraph

Article in Bioorganic & medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
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  4. Evaluation of anScientific reports · 2022
    Article
  5. Site-Specific and Residualizing Linker forJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Zhengyuan ZhouDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Satish K ChitneniDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Nick DevoogdtIn Vivo Cellular and Molecular Imaging Laboratory, Vrije Universiteit Brussel, (VUB), 1090 Brussels, Belgium.
Michael R ZalutskyDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA.
Ganesan VaidyanathanDepartment of Radiology, Duke University Medical Center, Durham, NC 27710, USA. Electronic address: ganesan.v@duke.edu.
Duke Medical Center · USDuke University · USVrije Universiteit Brussel · BE

Funding

RADIOTHERAPY USING MONOCLONAL ANTIBODIES AND ASTATINER01CA042324 · NCI · DUKE UNIVERSITY · PI ZALUTSKY, MICHAEL ROD · 1985 to 2020
$4.6M
ASTATINE AND IODINE RADIOLABELED MONOCLONAL ANTIBODIESR37CA042324 · NCI · DUKE UNIVERSITY · PI ZALUTSKY, MICHAEL ROD · 1999 to 2008
$3.8M
Labeling nanobodies with 18F residualizing labels for HER2 specific PET imagingR01CA188177 · NCI · DUKE UNIVERSITY · PI VAIDYANATHAN, GANESAN · 2015 to 2019
$1.8M
NCI NIH HHS R01 CA042324NCI NIH HHS R01 CA188177NCI NIH HHS R37 CA042324
6 · The paper itself

Abstract

In a previous study, we evaluated a HER2-specific single domain antibody fragment (sdAb) 2Rs15d labeled with

Indexed as

AnimalsBreast NeoplasmsCaproatesCell Line, TumorClick ChemistryErb-b2 Receptor Tyrosine KinasesFemaleFluorine RadioisotopesHumansMiceMice, NudePositron Emission Tomography Computed TomographyRadiopharmaceuticalsSingle-Domain AntibodiesTissue DistributionTransplantation, HeterologousCaproatesErb-b2 Receptor Tyrosine KinasesFluorine-18Fluorine Radioisotopeshexanoic acidRadiopharmaceuticalsSingle-Domain AntibodiesFluorine-18HER2Residualizing labelStrain-promoted click reactionVHH

Identifiers

PMID29534937
PMCPMC5891353
OpenAlexW2793087972

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.