Evidence map›Paper›PMID 29534854›Full record

ReviewTrends in microbiology2018

Within-Host Evolution of Human Influenza Virus.

Katherine S Xue, Louise H Moncla, Trevor Bedford, Jesse D Bloom

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 141 citations in OpenAlex.

  1. Trial
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  7. bronko: ultrafast, alignment-free detection of viral genome variation.bioRxiv : the preprint server for biology · 2026
    Article
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  12. Coinfection by multipleMicrobiology and molecular biology reviews : MMBR · 2025
    Review
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  15. Review
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17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Katherine S XueDepartment of Genome Sciences, University of Washington, Seattle, WA, USA; Division of Basic Sciences and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Louise H MonclaVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Trevor BedfordVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jesse D BloomDepartment of Genome Sciences, University of Washington, Seattle, WA, USA; Division of Basic Sciences and Computational Biology Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: jbloom@fredhutch.org.
Fred Hutch Cancer Center · USUniversity of Washington · US

Funding

Real-time tracking of virus evolution for vaccine strain selection and epidemiological investigationR35GM119774 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BEDFORD, TREVOR BC · 2016 to 2025
$4.1M
Viral Pathogenesis Training ProgramT32AI083203 · NIAID · UNIVERSITY OF WASHINGTON · PI BLOOM, JESSE D, LAGUNOFF, MICHAEL · 2009 to 2023
$2.7M
High-throughput experiments to guide influenza vaccine strain selectionR01AI127893 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BLOOM, JESSE D · 2016 to 2020
$2.1M
Mapping epistasis in molecular evolution: the influenza nucleoproteinR01GM102198 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BLOOM, JESSE D · 2012 to 2016
$1.6M
FHCRC High-Performance Computing ClusterS10OD020069 · OD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L · 2015 to 2015
$600k
NIAID NIH HHS R01 AI127893NIAID NIH HHS T32 AI083203NIGMS NIH HHS R01 GM102198NIGMS NIH HHS R35 GM119774NIH HHS S10 OD020069
6 · The paper itself

Abstract

The rapid global evolution of influenza virus begins with mutations that arise de novo in individual infections, but little is known about how evolution occurs within hosts. We review recent progress in understanding how and why influenza viruses evolve within human hosts. Advances in deep sequencing make it possible to measure within-host genetic diversity in both acute and chronic influenza infections. Factors like antigenic selection, antiviral treatment, tissue specificity, spatial structure, and multiplicity of infection may affect how influenza viruses evolve within human hosts. Studies of within-host evolution can contribute to our understanding of the evolutionary and epidemiological factors that shape influenza virus's global evolution.

Indexed as

Evolution, MolecularAntigens, ViralAntiviral AgentsDrug Resistance, ViralGenetic VariationGenome, ViralHigh-Throughput Nucleotide SequencingHost-Pathogen InteractionsHumansInfluenza A virusInfluenza, HumanMutationMutation RateOrgan SpecificityVirus ReplicationAntigens, ViralAntiviral Agentsdeep sequencingevolutioninfluenzawithin-host

Identifiers

PMID29534854
PMCPMC6097882
OpenAlexW2793516985

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.