ArticleEpidemiology and infection2018
The changing HIV-1 genetic characteristics and transmitted drug resistance among recently infected population in Yunnan, China.
Article in Epidemiology and infection, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Emergence of two novel HIV-1 Circulating Recombinant Forms (CRF190_0708 and CRF191_0708): molecular characterization and clinical insights from a five-year study in Yunnan, China.BMC microbiology · 2026Trial
- Prevalence of drug resistance mutations in low-level viremia patients under antiretroviral therapy in Southwestern China: a cross-sectional study.The Journal of antimicrobial chemotherapy · 2025Article
- Rapid circulation of HIV-1 CRF85_BC in Southwest China: its geographic origins and molecular transmission networks analysis.Frontiers in cellular and infection microbiology · 2025Article
- Characterization of a New HIV-1 Circulating Recombinant Form CRF142_BC - Yunnan, China, 2015 and 2021.China CDC weekly · 2024Article
- Article
- Genetic characterization of HIV-1 viruses among cases with antiretroviral therapy failure in Suzhou City, China.AIDS research and therapy · 2023Article
- Genetic polymorphisms in thePeerJ · 2023Article
- Identification of two novel HIV-1 circulating recombinant forms of CRF111_01C and CRF116_0108 in southwestern Yunnan, China.Virulence · 2022Article
- Construction of Machine Learning Models to Predict Changes in Immune Function Using Clinical Monitoring Indices in HIV/AIDS Patients After 9.9-Years of Antiretroviral Therapy in Yunnan, China.Frontiers in cellular and infection microbiology · 2022Article
- Using molecular network analysis to explore the characteristics of HIV-1 transmission in a China-Myanmar border area.PloS one · 2022Article
- HIV drug resistance and HIV transmission risk factors among newly diagnosed individuals in Southwest China.BMC infectious diseases · 2021Article
- Patterns and risk of HIV-1 transmission network among men who have sex with men in Guangxi, China.Scientific reports · 2021Article
- A thematic analysis of experiences of HIV risks among female sex workers in the Yunnan-Vietnam Chinese border region.BMC women's health · 2021Article
- Using Molecular Transmission Networks to Reveal the Epidemic of Pretreatment HIV-1 Drug Resistance in Guangxi, China.Frontiers in genetics · 2021Article
- Clinical characteristics and outcomes in HIV-associated diffuse large B-cell lymphoma in China: A retrospective single-center study.Journal of Cancer · 2021Article
- Frequently Transmission and Close Relationship Among Immigrants in the China-Myanmar Border Region Indicated by Molecular Transmission Analysis From a Cross-Sectional Data.Frontiers in medicine · 2021Article
- Characterization of subtypes and transmitted drug resistance strains of HIV among Beijing residents between 2001-2016.PloS one · 2020Article
- HIV-1 Drug Resistance, Distribution of Subtypes, and Drug Resistance-Associated Mutations in Virologic Failure Individuals in Chengdu, Southwest China, 2014-2016.BioMed research international · 2020Article
- Demographic characteristics and spatial clusters of recent HIV-1 infections among newly diagnosed HIV-1 cases in Yunnan, China, 2015.BMC public health · 2019Article
- Spatial clusters of HIV-1 genotypes in a recently infected population in Yunnan, China.BMC infectious diseases · 2019Article
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16 authors.
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Abstract
Multiple human immunodeficiency virus (HIV)-1 genotypes in China were first discovered in Yunnan Province before disseminating throughout the country. As the HIV-1 epidemic continues to expand in Yunnan, genetic characteristics and transmitted drug resistance (TDR) should be further investigated among the recently infected population. Among 2828 HIV-positive samples newly reported in the first quarter of 2014, 347 were identified as recent infections with BED-captured enzyme immunoassay (CEIA). Of them, 291 were successfully genotyped and identified as circulating recombinant form (CRF)08_BC (47.4%), unique recombinant forms (URFs) (18.2%), CRF01_AE (15.8%), CRF07_BC (14.4%), subtype C (2.7%), CRF55_01B (0.7%), subtype B (0.3%) and CRF64_BC (0.3%). CRF08_BC and CRF01_AE were the predominant genotypes among heterosexual and homosexual infections, respectively. CRF08_BC, URFs, CRF01_AE and CRF07_BC expanded with higher prevalence in central and eastern Yunnan. The recent common ancestor of CRF01_AE, CRF07_BC and CRF08_BC dated back to 1983.1, 1992.1 and 1989.5, respectively. The effective population sizes (EPS) for CRF01_AE and CRF07_BC increased exponentially during 1991-1999 and 1994-1999, respectively. The EPS for CRF08_BC underwent two exponential growth phases in 1994-1998 and 2001-2002. Lastly, TDR-associated mutations were identified in 1.8% of individuals. These findings not only enhance our understanding of HIV-1 evolution in Yunnan but also have implications for vaccine design and patient management strategies.
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