Evidence map›Paper›PMID 29534471›Full record

ReviewInternational journal of molecular sciences2018

Nanoparticle Exposure and Hormetic Dose-Responses: An Update.

Ivo Iavicoli, Veruscka Leso, Luca Fontana, Edward J Calabrese

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

  1. Article
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  3. Review
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  6. CeOPlant molecular biology · 2026
    Review
  7. Review
  8. Review
  9. Article
  10. Article
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  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Evaluation of Molecular Responses and Longevity Markers inInternational journal of molecular sciences · 2026
    Article
  18. Review
  19. Review
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ivo IavicoliDepartment of Public Health, University of Naples Federico II, 80131 Naples, Italy. ivo.iavicoli@unina.it.ORCID 0000-0003-0444-3792
Veruscka LesoDepartment of Public Health, University of Naples Federico II, 80131 Naples, Italy. veruscka.leso@gmail.com.
Luca FontanaInstitute of Public Health, Catholic University of Sacred Heart, 00168 Rome, Italy. lfontana73@yahoo.it.
Edward J CalabreseDepartment of Environmental Health Sciences, University of Massachusetts, Amherst, MA 01003, USA. edwardc@schoolph.umass.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The concept of hormesis, as an adaptive response of biological systems to moderate environmental challenges, has raised considerable nano-toxicological interests in view of the rapid pace of production and application of even more innovative nanomaterials and the expected increasing likelihood of environmental and human exposure to low-dose concentrations. Therefore, the aim of this review is to provide an update of the current knowledge concerning the biphasic dose-responses induced by nanoparticle exposure. The evidence presented confirmed and extended our previous findings, showing that hormesis is a generalized adaptive response which may be further generalized to nanoscale xenobiotic challenges. Nanoparticle physico-chemical properties emerged as possible features affecting biphasic relationships, although the molecular mechanisms underlining such influences remain to be fully understood, especially in experimental settings resembling long-term and low-dose realistic environmental exposure scenarios. Further investigation is necessary to achieve helpful information for a suitable assessment of nanomaterial risks at the low-dose range for both the ecosystem function and the human health.

Indexed as

HormesisAnimalsCell LineHumansMetal NanoparticlesSpecies Specificitydose–response relationshiphormesislow dosesnanomaterial

Identifiers

PMID29534471
PMCPMC5877666

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.