Evidence map›Paper›PMID 29534467›Full record

ArticleInternational journal of molecular sciences2018

Expanding the Utilization of Formalin-Fixed, Paraffin-Embedded Archives: Feasibility of miR-Seq for Disease Exploration and Biomarker Development from Biopsies with Clear Cell Renal Cell Carcinoma.

Philipp Strauss, Hans-Peter Marti, Christian Beisland, Andreas Scherer, Vegard Lysne, Sabine Leh, Arnar Flatberg, Even Koch, Vidar Beisvag, Lea Landolt and 2 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Philipp StraussDepartment of Clinical Medicine, University of Bergen, 5021 Bergen, Norway. philipp.strauss@uib.no.
Hans-Peter MartiDepartment of Clinical Medicine, University of Bergen, 5021 Bergen, Norway.
Christian BeislandDepartment of Clinical Medicine, University of Bergen, 5021 Bergen, Norway. christian.beisland@uib.no.ORCID 0000-0002-3216-4937
Andreas SchererSpheromics, 81100 Kontiolahti, Finland. andreas.scherer@spheromics.com.
Vegard LysneDepartment of Clinical Science, University of Bergen, 5021 Bergen, Norway. vegard.lysne@uib.no.ORCID 0000-0002-0816-5075
Sabine LehDepartment of Clinical Medicine, University of Bergen, 5021 Bergen, Norway. sabine.leh@helse-bergen.no.ORCID 0000-0002-0764-2941
Arnar FlatbergDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway. arnar.flatberg@ntnu.no.
Even KochDepartment of Clinical Medicine, University of Bergen, 5021 Bergen, Norway. even.koch@uib.no.
Vidar BeisvagDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway. vidar.beisvag@ntnu.no.
Lea LandoltDepartment of Clinical Medicine, University of Bergen, 5021 Bergen, Norway. lea.landolt@uib.no.
Trude SkogstrandDepartment of Medicine, Haukeland University Hospital, 5021 Bergen, Norway. trude.skogstrand@uib.no.
Øystein EikremDepartment of Clinical Medicine, University of Bergen, 5021 Bergen, Norway. oystein.eikrem@uib.no.ORCID 0000-0002-1783-5552

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Novel predictive tools for clear cell renal cell carcinoma (ccRCC) are urgently needed. MicroRNAs (miRNAs) have been increasingly investigated for their predictive value, and formalin-fixed paraffin-embedded biopsy archives may potentially be a valuable source of miRNA sequencing material, as they remain an underused resource. Core biopsies of both cancerous and adjacent normal tissues were obtained from patients (

Indexed as

AgedBiomarkers, TumorCarcinoma, Renal CellFemaleFormaldehydeHumansKidney NeoplasmsMaleMicroRNAsMiddle AgedParaffin EmbeddingTissue FixationBiomarkers, TumorFormaldehydeMicroRNAsclear cell renal cell carcinoma/ccRCCformalin-fixed paraffin-embedded/FFPEmicroRNA/miRNAmiR-155next generation sequencing/NGS

Identifiers

PMID29534467
PMCPMC5877664

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.