ArticleBritish journal of clinical pharmacology2018
'Massive' metformin overdose.
Article in British journal of clinical pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Metformin's Role in Hyperlactatemia and Lactic Acidosis in ICU Patients: A Systematic Review.Pharmacology · 2023Pooled it
- The Association between Metformin Therapy and Lactic Acidosis.Drug safety · 2019Pooled it
- Metformin-associated lactic acidosis: A mini review of pathophysiology, diagnosis and management in critically ill patients.World journal of diabetes · 2024Review
- Daily dose of metformin caused acute kidney injury with lactic acidosis: a case report.Journal of medical case reports · 2023Article
- Metformin toxicity: A meta-summary of case reports.World journal of diabetes · 2022Article
- AMPK-mediated potentiation of GABAergic signalling drives hypoglycaemia-provoked spike-wave seizures.Brain : a journal of neurology · 2022Article
- Spontaneously Reported Adverse Drug Reactions and Their Description in Hospital Discharge Reports: A Retrospective Study.Journal of clinical medicine · 2021Article
- Profound Metabolic Acidosis due to Metformin Intoxication Requiring Dialysis.Case reports in nephrology · 2021Article
- Increasing metformin concentrations and its excretion in both rat and porcine ex vivo normothermic kidney perfusion model.BMJ open diabetes research & care · 2020Article
- Article
- The pharmacokinetics of metformin in patients receiving intermittent haemodialysis.British journal of clinical pharmacology · 2020Article
- Metformin-Induced Lactic Acidosis: A Question of Time.Case reports in critical care · 2020Article
- Sustained low-efficiency dialysis for metformin-associated lactic acidosis in patients with acute kidney injury.Journal of nephrology · 2019Article
- 'Massive' metformin overdose.British journal of clinical pharmacology · 2018Article
- Response to 'Comment on ''Massive' metformin overdose' by Chiew et al.'British journal of clinical pharmacology · 2018Article
- Comment on ''Massive' metformin overdose' by Chiew et al.British journal of clinical pharmacology · 2018Article
- Complex decisions in the use of extracorporeal treatments in acute metformin overdose: which modality, when and how to measure the effect.British journal of clinical pharmacology · 2018Article
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Authors and funding
8 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Massive metformin overdose can cause metabolic acidosis with hyperlactatemia. A 55-year-old woman presented 5 h after multidrug overdose, including 132 g extended-release metformin. Continuous venovenous haemodiafiltration (CVVHDF) and noradrenaline were commenced due to metabolic acidosis (pH 7.0, lactate 17 mmol l
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.