Evidence map›Paper›PMID 29534299›Full record

ReviewAnnals of neurology2018

Getting the best outcomes from epilepsy surgery.

Vejay N Vakharia, John S Duncan, Juri-Alexander Witt, Christian E Elger, Richard Staba, Jerome Engel

Erratum issued Registry-linked trialOpen access · hybridAbstract readReview
In one paragraph

Review in Annals of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04553354 (Evaluation of Safety and Efficacy of Cortical Resections for Seizure Control for Patients With Drug Resistant Epilepsy), which is not on this map. Cited by 92 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 4 pooled it
17.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04553354 unknown statusnot on this mapstarted 2020, after this paper: background citation

Evaluation of Safety and Efficacy of Cortical Resections for Seizure Control for Patients With Drug Resistant Epilepsy

TypeobservationalSponsorAssiut UniversityRan2020 to 2022Enrolled35ConditionsEpilepsy Surgery, Drug Resistant EpilepsyArmscortical resections
3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 4 syntheses or guidelines pooled it, 244 citations in OpenAlex.

  1. Factors predicting the response to vagus nerve stimulation (VNS) in pediatric patients with drug- resistant epilepsy: a systematic review and meta-analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Vejay N VakhariaDepartment of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom, and Chalfont Centre for Epilepsy.ORCID 0000-0002-9476-4225
John S DuncanDepartment of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, United Kingdom, and Chalfont Centre for Epilepsy.
Juri-Alexander WittDepartment of Epileptology, University of Bonn Medical Center, Bonn, Germany.
Christian E ElgerDepartment of Epileptology, University of Bonn Medical Center, Bonn, Germany.
Richard StabaDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
Jerome EngelDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA.
Epilepsy Research UK · GBUniversity of Bonn · DEUniversity of California, Los Angeles · US

Funding

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Public Engagement CoreU54NS100064 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2017 to 2021
$21.7M
SYSTEMS PATHOPHYSIOLOGYP01NS002808 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRAGIN, ANATOL · 1985 to 2010
$13.5M
Early Randomized Surgical Epilepsy TrialU01NS042372 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ENGEL, JEROME NONE · 2002 to 2007
$9.8M
IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUSR01NS033310 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JEROME NONE ENGEL, Richard Staba · 1994 to 2026
$7.5M
IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUSR37NS033310 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ENGEL, JEROME NONE · 2004 to 2010
$3.2M
The Epilepsy Bioinformatics Study (EpiBioS)P20NS080181 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ENGEL, JEROME NONE, HOVDA, DAVID A · 2012 to 2014
$1.7M
Department of HealthNINDS NIH HHS P01 NS002808NINDS NIH HHS R01 NS033310NINDS NIH HHS R37 NS033310NINDS NIH HHS U01 NS042372NINDS NIH HHS U54 NS100064Wellcome TrustWellcome Trust WT106882
6 · The paper itself

Abstract

Neurosurgery is an underutilized treatment that can potentially cure drug-refractory epilepsy. Careful, multidisciplinary presurgical evaluation is vital for selecting patients and to ensure optimal outcomes. Advances in neuroimaging have improved diagnosis and guided surgical intervention. Invasive electroencephalography allows the evaluation of complex patients who would otherwise not be candidates for neurosurgery. We review the current state of the assessment and selection of patients and consider established and novel surgical procedures and associated outcome data. We aim to dispel myths that may inhibit physicians from referring and patients from considering neurosurgical intervention for drug-refractory focal epilepsies. Ann Neurol 2018;83:676-690.

Indexed as

Treatment OutcomeEpilepsyHumansNeurosurgical Procedures

Identifiers

PMID29534299
PMCPMC5947666
OpenAlexW2792435683

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.