ArticleBrain : a journal of neurology2018
Artificial limb representation in amputees.
Article in Brain : a journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Prosthetic embodiment: systematic review on definitions, measures, and experimental paradigms.Journal of neuroengineering and rehabilitation · 2022Pooled it
- Brain lateralization in children with upper-limb reduction deficiency.Journal of neuroengineering and rehabilitation · 2021Trial
- Dissociating the hierarchical processing of perceptual and food category information under different task demands.Psychonomic bulletin & review · 2026Article
- Global remapping of the sensory homunculus emerges early in childhood development.Nature communications · 2026Article
- Functional and Structural Neural Plasticity Following sEMG Control of a Virtual Prosthetic Hand in an Individual with Bilateral Upper-Limb Congenital Amputation.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025Article
- The Use of ABILHAND-Kids in Children with Unilateral Congenital Below-Elbow Deficiencies and Acquired Amputation: An Italian Cross-Sectional Study.Children (Basel, Switzerland) · 2024Article
- Processing Language Partly Shares Neural Genetic Basis with Processing Tools and Body Parts.eNeuro · 2024Article
- Prosthetic home intervention induces cortical plasticity in paediatrics with congenital limb reduction.Brain communications · 2024Article
- Grasping with a Twist: Dissociating Action Goals from Motor Actions in Human Frontoparietal Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Embodiment for Robotic Lower-Limb Exoskeletons: A Narrative Review.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2023Article
- Loss of action-related function and connectivity in the blind extrastriate body area.Frontiers in neuroscience · 2023Article
- Use-dependent increase in attention to the prosthetic foot in patients with lower limb amputation.Scientific reports · 2022Article
- Getting a Child a Myoelectric Prosthesis: Did We Miss the Bus?Journal of prosthetics and orthotics : JPO · 2022Article
- Physiological and Neural Changes with Rehabilitation Training in a 53-Year Amputee: A Case Study.Brain sciences · 2022Article
- Subjective Response Measurement to Prosthesis or Device Use: Validation of the Prosthetic-Bionic Paradigm Questionnaire (PBP-Q).International journal of environmental research and public health · 2022Article
- Motor Imagery-Related Changes of Neural Oscillation in Unilateral Lower Limb Amputation.Frontiers in neuroscience · 2022Article
- Embodiment of a virtual prosthesis through training using an EMG-based human-machine interface: Case series.Frontiers in human neuroscience · 2022Article
- Early life experience sets hard limits on motor learning as evidenced from artificial arm use.eLife · 2021Article
- Hand-Selective Visual Regions Represent How to Grasp 3D Tools: Brain Decoding during Real Actions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Robotic hand augmentation drives changes in neural body representation.Science robotics · 2021Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 4 countries.
Funding
Abstract
The human brain contains multiple hand-selective areas, in both the sensorimotor and visual systems. Could our brain repurpose neural resources, originally developed for supporting hand function, to represent and control artificial limbs? We studied individuals with congenital or acquired hand-loss (hereafter one-handers) using functional MRI. We show that the more one-handers use an artificial limb (prosthesis) in their everyday life, the stronger visual hand-selective areas in the lateral occipitotemporal cortex respond to prosthesis images. This was found even when one-handers were presented with images of active prostheses that share the functionality of the hand but not necessarily its visual features (e.g. a 'hook' prosthesis). Further, we show that daily prosthesis usage determines large-scale inter-network communication across hand-selective areas. This was demonstrated by increased resting state functional connectivity between visual and sensorimotor hand-selective areas, proportional to the intensiveness of everyday prosthesis usage. Further analysis revealed a 3-fold coupling between prosthesis activity, visuomotor connectivity and usage, suggesting a possible role for the motor system in shaping use-dependent representation in visual hand-selective areas, and/or vice versa. Moreover, able-bodied control participants who routinely observe prosthesis usage (albeit less intensively than the prosthesis users) showed significantly weaker associations between degree of prosthesis observation and visual cortex activity or connectivity. Together, our findings suggest that altered daily motor behaviour facilitates prosthesis-related visual processing and shapes communication across hand-selective areas. This neurophysiological substrate for prosthesis embodiment may inspire rehabilitation approaches to improve usage of existing substitutionary devices and aid implementation of future assistive and augmentative technologies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.