Evidence map›Paper›PMID 29534031›Full record

ReviewNutrients2018

l-Carnitine Supplementation in Recovery after Exercise.

Roger Fielding, Linda Riede, James P Lugo, Aouatef Bellamine

Erratum issuedOpen access · goldAbstract readReview
In one paragraph

Review in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 63 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.

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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Roger FieldingTufts University, 136 Harrison Avenue, Boston, MA 02111, USA. roger.Fielding@tufts.edu.
Linda Riedeanalyze & realize GmbH, Waldseeweg 6, 13467 Berlin, Germany. lriede@a-r.com.
James P LugoLonza Inc., 90 Boroline Road, Allendale, NJ 07401, USA. jim.lugo@lonza.com.
Aouatef BellamineLonza Inc., 90 Boroline Road, Allendale, NJ 07401, USA. aouatef.bellamine@lonza.com.
Lonza (United States) · USAnalyze & Realize (Germany) · DETufts University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Given its pivotal role in fatty acid oxidation and energy metabolism, l-carnitine has been investigated as ergogenic aid for enhancing exercise capacity in the healthy athletic population. Early research indicates its beneficial effects on acute physical performance, such as increased maximum oxygen consumption and higher power output. Later studies point to the positive impact of dietary supplementation with l-carnitine on the recovery process after exercise. It is demonstrated that l-carnitine alleviates muscle injury and reduces markers of cellular damage and free radical formation accompanied by attenuation of muscle soreness. The supplementation-based increase in serum and muscle l-carnitine contents is suggested to enhance blood flow and oxygen supply to the muscle tissue via improved endothelial function thereby reducing hypoxia-induced cellular and biochemical disruptions. Studies in older adults further showed that l-carnitine intake can lead to increased muscle mass accompanied by a decrease in body weight and reduced physical and mental fatigue. Based on current animal studies, a role of l-carnitine in the prevention of age-associated muscle protein degradation and regulation of mitochondrial homeostasis is suggested.

Indexed as

Dietary SupplementsEvidence-Based MedicineExerciseSports Nutritional Physiological PhenomenaAdultAgedAntioxidantsCarnitineElder Nutritional Physiological PhenomenaHumansMuscle, SkeletalMyalgiaOxidative StressPerformance-Enhancing SubstancesSarcopeniaAntioxidantsCarnitinePerformance-Enhancing Substancesagingexercise recovery">l-carnitinemuscle metabolismphysical performance

Identifiers

PMID29534031
PMCPMC5872767
OpenAlexW2794102661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.