Evidence map›Paper›PMID 29534010›Full record

ReviewMolecules (Basel, Switzerland)2018

Structural Diversity and Biological Activities of Novel Secondary Metabolites from Endophytes.

Han Gao, Gang Li, Hong-Xiang Lou

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Indian journal of microbiology · 2025
    Article
  5. Article
  6. Review
  7. Excavation of resources ofFrontiers in microbiology · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Description ofFrontiers in microbiology · 2024
    Article
  12. Article
  13. Indole Diterpene Derivatives from theMolecules (Basel, Switzerland) · 2023
    Article
  14. Endophytic fungi: a potential source for drugs against central nervous system disorders.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023
    Review
  15. Review
  16. Secondary metabolites from the Endophytic fungiFrontiers in microbiology · 2023
    Article
  17. Article
  18. Article
  19. A New Source of Diterpene Lactones FromFrontiers in microbiology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Han GaoDepartment of Natural Medicine and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266021, China. hg201602@163.com.
Gang LiDepartment of Natural Medicine and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266021, China. gang.li@qdu.edu.cn.ORCID 0000-0003-0621-2779
Hong-Xiang LouDepartment of Natural Medicine and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266021, China. louhongxiang@sdu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exploration of structurally novel natural products greatly facilitates the discovery of biologically active pharmacophores that are biologically validated starting points for the development of new drugs. Endophytes that colonize the internal tissues of plant species, have been proven to produce a large number of structurally diverse secondary metabolites. These molecules exhibit remarkable biological activities, including antimicrobial, anticancer, anti-inflammatory and antiviral properties, to name but a few. This review surveys the structurally diverse natural products with new carbon skeletons, unusual ring systems, or rare structural moieties that have been isolated from endophytes between 1996 and 2016. It covers their structures and bioactivities. Biosynthesis and/or total syntheses of some important compounds are also highlighted. Some novel secondary metabolites with marked biological activities might deserve more attention from chemists and biologists in further studies.

Indexed as

Biological ProductsEndophytesMolecular StructurePolyketidesSecondary MetabolismTerpenesBiological ProductsPolyketidesTerpenesbioactivitiesbiosynthesisendophytesnatural productsskeletons

Identifiers

PMID29534010
PMCPMC6017594

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.