ArticleGut microbes2018
Bacterial growth, flow, and mixing shape human gut microbiota density and composition.
Article in Gut microbes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- Comprehensive microbial and clinical profiling of functional constipation: A stratified comparative study of age and constipation subtype.World journal of gastroenterology · 2025Trial
- Growth capacity and mortality burden shape microbial persistence under osmotic stress inbioRxiv : the preprint server for biology · 2026Article
- Modulating microbial intake helps to maintain the gut microbiome diversity.Communications biology · 2026Article
- Article
- Quantifying the varying harvest of fermentation products from the human gut microbiota.bioRxiv : the preprint server for biology · 2025Article
- Immune cell profiling reveals diverse niches of immune residents of the enteric nervous system and potential neuroimmune interactions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Exploring the role of gut microbiota in rheumatoid arthritis: the effects of diet and drug supplementation.BMC rheumatology · 2025Article
- Prior antibiotics exposure is associated with an elevated risk of surgical site infections, including anastomotic leakage, after colon cancer but not rectal cancer surgery: A register-based study of 38,839 patients.International journal of cancer · 2025Article
- Diagnosing and engineering gut microbiomes.EMBO molecular medicine · 2024Review
- Metabolic interactions shape emergent biofilm structures in a conceptual model of gut mucosal bacterial communities.NPJ biofilms and microbiomes · 2024Article
- Bacterial interactions on nutrient-rich surfaces in the gut lumen.Infection and immunity · 2024Review
- Gastrointestinal Dysmotility Predisposes to Colitis through Regulation of Gut Microbial Composition and Linoleic Acid Metabolism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Assessing the impact of three feeding stages on rumen bacterial community and physiological characteristics of Japanese Black cattle.Scientific reports · 2024Article
- Article
- Boosting Fitness Costs Associated with Antibiotic Resistance in the Gut: On the Way to Biorestoration of Susceptible Populations.Biomolecules · 2024Review
- Structural analysis of type 3 resistant starch fromFrontiers in nutrition · 2024Article
- Healthy gut microbiomes are host-controllable microbiomes.Frontiers in microbiology · 2024Article
- Development of systemic and mucosal immune responses against gut microbiota in early life and implications for the onset of allergies.Frontiers in allergy · 2024Review
- Prediagnostic Prescription Antibiotics Use and Survival in Patients with Colorectal Cancer: A Swedish National Register-Based Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Mechanisms of Lung and Intestinal Microbiota and Innate Immune Changes Caused by Pathogenic Enterococcus Faecalis Promoting the Development of Pediatric Pneumonia.Microorganisms · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The human gut microbiota is highly dynamic, and host physiology and diet exert major influences on its composition. In our recent study, we integrated new quantitative measurements on bacterial growth physiology with a reanalysis of published data on human physiology to build a comprehensive modeling framework. This can generate predictions of how changes in different host factors influence microbiota composition. For instance, hydrodynamic forces in the colon, along with colonic water absorption that manifests as transit time, exert a major impact on microbiota density and composition. This can be mechanistically explained by their effect on colonic pH which directly affects microbiota competition for food. In this addendum, we describe the underlying analysis in more detail. In particular, we discuss the mixing dynamics of luminal content by wall contractions and its implications for bacterial growth and density, as well as the broader implications of our insights for the field of gut microbiota research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.