ArticleCancer medicine2018
Polymorphism rs2682818 in miR-618 is associated with colorectal cancer susceptibility in a Han Chinese population.
Article in Cancer medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- mirSNPs as Potential Colorectal Cancer Biomarkers: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Does miR-618 rs2682818 variant affect cancer susceptibility? Evidence from 10 case-control studies.Bioscience reports · 2019Pooled it
- Article
- Genetic Regulation of Human isomiR Biogenesis.Cancers · 2023Article
- Regulatory Roles of Noncoding RNAs in the Progression of Gastrointestinal Cancers and Health Disparities.Cells · 2022Review
- CircRNA circ-ATAD1 suppresses miR-618 maturation to participate in colorectal cancer.BMC gastroenterology · 2022Article
- Single Nucleotide Polymorphisms in microRNA Genes and Colorectal Cancer Risk and Prognosis.Biomedicines · 2022Review
- Polymorphism rs2682818 participates in the progression of colorectal carcinoma via miR-618-TIMP1 regulatory axis.Scientific reports · 2021Article
- Circulating miR-618 Has Prognostic Significance in Patients with Metastatic Colon Cancer.Current oncology (Toronto, Ont.) · 2021Article
- miR-618 rs2682818 C>A polymorphism decreases Hirschsprung disease risk in Chinese children.Bioscience reports · 2020Article
- Genetic Variants in miRNAs Are Associated With Risk of Non-syndromic Tooth Agenesis.Frontiers in physiology · 2020Article
- Observational
- Polymorphism rs2682818 in miR-618 is associated with colorectal cancer susceptibility in a Han Chinese population.Cancer medicine · 2018Article
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs), endogenous small noncoding RNAs (ncRNAs), play crucial roles in cancer development. Many studies have demonstrated that miRNAs can serve as diagnostic and therapeutic biomarkers for malignancies. Additionally, single nucleotide polymorphisms (SNPs) located in miRNA functional regions have been reported to be involved in cancer susceptibility. In this study, we investigated the associations between SNPs located in miRNA functional regions and colorectal cancer (CRC) susceptibility. We systematically screened all candidate miRNAs and their SNPs and then evaluated the relationships between the SNPs and CRC susceptibility in a Han Chinese population including 878 patients with CRC and 884 controls. Genotyping was performed by TaqMan assay. After comprehensively screening the miRNAs and SNPs, we elected to evaluate the association between SNP rs2682818 in miR-618 and CRC susceptibility. We found that the AA and AC/AA genotypes of rs2682818 were associated with a decreased risk of CRC compared with the CC genotype (odds ratio (OR) = 0.54, 95% confidence interval (CI) = 0.37-0.79 for AA vs. CC in codominant model; OR = 0.82, 95% CI = 0.68-0.99 for AC/AA vs. CC in dominant model). However, we obtained no statically significant results in our subgroup analyses. SNP rs2682818 in miR-618 has potential as a biomarker for individuals with high CRC susceptibility. Our findings need to be verified in studies including larger samples. Moreover, molecular functional studies of miR-681 must be performed to confirm its relationship with CRC.
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