When motor unit expansion in ageing muscle fails, atrophy ensues.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

12 citing papers in PubMed.

1. Determination of the essential number of motoneurons required to produce functionally useful hind limb locomotion.Neural regeneration research · 2026
   Article
2. From molecular to physical function: The aging trajectory.Current research in physiology · 2025
   Review
3. Inhibition of NF-κB with an Analog of Withaferin-A Restores TDP-43 Homeostasis and Proteome Profiles in a Model of Sporadic ALS.Biomedicines · 2024
   Article
4. Chemogenetic inhibition of TrkB signalling reduces phrenic motor neuron survival and size.Molecular and cellular neurosciences · 2023
   Article
5. The emerging role of the sympathetic nervous system in skeletal muscle motor innervation and sarcopenia.Ageing research reviews · 2021
   Review
6. Diaphragm neuromuscular transmission failure in a mouse model of an early-onset neuromotor disorder.Journal of applied physiology (Bethesda, Md. : 1985) · 2021
   Article
7. Semiautomatic morphometric analysis of skeletal muscle obtained by needle biopsy in older adults.GeroScience · 2020
   Article
8. Impaired neuromuscular transmission of the tibialis anterior in a rodent model of hypertonia.Journal of neurophysiology · 2020
   Article
9. The Dunkin Hartley Guinea Pig Is a Model of Primary Osteoarthritis That Also Exhibits Early Onset Myofiber Remodeling That Resembles Human Musculoskeletal Aging.Frontiers in physiology · 2020
   Article
10. Diaphragm neuromuscular transmission failure in aged rats.Journal of neurophysiology · 2019
    Article
11. Aberrant redox signalling and stress response in age-related muscle decline: Role in inter- and intra-cellular signalling.Free radical biology & medicine · 2019
    Review
12. Skeletal Muscle Function in the Oldest-Old: The Role of Intrinsic and Extrinsic Factors.Exercise and sport sciences reviews · 2018
    Review

Corrections and comments

• Comment on
  Failure to expand the motor unit size to compensate for declining motor unit numbers distinguishes sarcopenic from non-sarcopenic older men.2018

Authors and funding

1 author.

Funding

Abstract

PubMed holds no abstract for this paper.

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