ArticleJournal of endocrinological investigation2018
Body composition and metabolic changes during a 520-day mission simulation to Mars.
Article in Journal of endocrinological investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Impact of spaceflight on endocrine, metabolic and kidney function: current evidence, open issues, and potential countermeasures.BMC biology · 2025Review
- Gut microbiome, stress and interventional strategies using hardy animals.Future science OA · 2025Review
- Behavioral adaptation in diet maintains nutrient composition in an isolated, confined, and extreme environment in Antarctica.Frontiers in nutrition · 2025Article
- How do gravity alterations affect animal and human systems at a cellular/tissue level?NPJ microgravity · 2023Article
- Space Flight-Promoted Insulin Resistance as a Possible Disruptor of Wound Healing.Frontiers in bioengineering and biotechnology · 2022Review
- 4 days in dry immersion increases arterial wall response to ultrasound wave as measured using radio-frequency signal, comparison with spaceflight data.Frontiers in physiology · 2022Article
- Robot-assisted surgery in space: pros and cons. A review from the surgeon's point of view.NPJ microgravity · 2021Review
- The Impact of COVID-19-Related Lockdown on Diet and Serum Markers in Healthy Adults.Nutrients · 2021Article
- Reanalysis of the Mars500 experiment reveals common gut microbiome alterations in astronauts induced by long-duration confinement.Computational and structural biotechnology journal · 2021Article
- Effect of Unloading Condition on the Healing Process and Effectiveness of Platelet Rich Plasma as a Countermeasure: Study on In Vivo and In Vitro Wound Healing Models.International journal of molecular sciences · 2020Article
- Physiological Acclimatization of the Liver to 180-Day Isolation and the Mars Solar Day.BioMed research international · 2020Article
- Multi-System Adaptation to Confinement During the 180-Day Controlled Ecological Life Support System (CELSS) Experiment.Frontiers in physiology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
Abstract
purposeThe "Mars-500 project" allowed to evaluate the changes in psychological/physiological adaptation over a prolonged confinement, in order to gather information for future missions. Here, we evaluated the impact of confinement and isolation on body composition, glucose metabolism/insulin resistance and adipokine levels.
methodsThe "Mars-500 project" consisted of 520 consecutive days of confinement from June 3, 2010 to Nov 4, 2011. The crew was composed of six male subjects (three Russians, two Europeans, and one Chinese) with a median age of 31 years (range 27-38 years).
resultsDuring the 520-day confinement, total body mass and BMI progressively decreased, reaching a significant difference at the end (417 days) of the observation period (- 9.2 and - 5.5%, respectively). Fat mass remained unchanged. A progressive and significant increase of fasting plasma glucose was observed between 249 and 417 days (+ 10/+ 17% vs baseline), with a further increase at the end of confinement (up to + 30%). Median plasma insulin showed a non-significant early increment (60 days; + 86%). Total adiponectin halved (- 47%) 60 days after hatch closure, remaining at this nadir (- 51%) level for a further 60 days. High molecular weight adiponectin remained significantly lower from 60 to 168 days.
conclusionsBased on these data, countermeasures may be envisioned to balance the potentially harmful effects of prolonged confinement, including a better exercise program, with accurate monitoring of (1) the individual activity and (2) the relationship between body composition and metabolic derangement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.