ArticleAnnals of surgical oncology2018
Outcomes After Distal Pancreatectomy with Celiac Axis Resection for Pancreatic Cancer: A Pan-European Retrospective Cohort Study.
Article in Annals of surgical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.
- Systematic review and meta-analysis of contemporary pancreas surgery with arterial resection.Langenbeck's archives of surgery · 2020Pooled it
- Article
- Distal and Total Pancreatectomy With En Bloc Celiac Axis Resection for Pancreatic Cancer at a High-Volume Center.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2026Article
- Real-world short-term outcomes after distal pancreatectomy with en bloc celiac axis resection using the National clinical database of Japan.Surgery today · 2026Article
- Hybrid hepatic artery debranching for pancreatic cancer with celiac axis occlusion.Hepatobiliary surgery and nutrition · 2026Article
- Distal Pancreatectomy with Celiac Axis and Venous Resection with Hepatic Artery and Venous Reconstruction (DP-CARV) for Locally Advanced Pancreatic Adenocarcinoma.Annals of surgical oncology · 2025Article
- Laparoscopic Radical Antegrade Modular Pancreatosplenectomy with Portal Vein Reconstruction and Celiac Axis Resection for Pancreatic Neck-Body Cancer.Annals of surgical oncology · 2025Article
- Article
- Evolution and improved outcomes in the era of multimodality treatment for extended pancreatectomy.BJS open · 2024Article
- Successful treatment for pseudoaneurysm following distal pancreatectomy with celiac axis resection without postoperative pancreatic fistula: a case report.Surgical case reports · 2024Article
- Relaparotomy pseudoaneurysm repair after distal pancreatectomy with celiac axis resection (DP-CAR): a case report.Journal of surgical case reports · 2024Article
- Preoperative chemotherapy, radiotherapy and surgical decision-making in patients with borderline resectable and locally advanced pancreatic cancer.Nature reviews. Gastroenterology & hepatology · 2024Review
- Article
- Modified Appleby: experience improves short-term results, but is it enough?Hepatobiliary surgery and nutrition · 2023Article
- Predictive factors for survival in borderline resectable and locally advanced pancreatic cancer: are these really two different entities?BMC surgery · 2023Article
- Pancreatectomy with resection and reconstruction of the superior mesenteric artery.The British journal of surgery · 2023Article
- ASO Author Reflections: How to Tackle the Vascular Risk of Celiac Axis Resection for Pancreatic Cancer?Annals of surgical oncology · 2023Article
- Distal pancreatectomy with or without radical approach, vascular resections and splenectomy: Easier does not always mean easy.World journal of gastrointestinal surgery · 2023Review
- Article
- Technical options in surgery for artery-involving pancreatic cancer: Invasion depth matters.Surgery open science · 2023Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
38 authors at 13 institutions in 12 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWestern multicenter studies on distal pancreatectomy with celiac axis resection (DP-CAR), also known as the Appleby procedure, for locally advanced pancreatic cancer are lacking. We aimed to study overall survival, morbidity, mortality and the impact of preoperative hepatic artery embolization (PHAE).
methodsRetrospective cohort study within the European-African Hepato-Pancreato-Biliary-Association, on DP-CAR between 1-1-2000 and 6-1-2016. Primary endpoint was overall survival. Secondary endpoints were radicality (R0-resection), 90-day mortality, major morbidity, and pancreatic fistulae (grade B/C).
resultsWe included 68 patients from 20 hospitals in 12 countries. Postoperatively, 53% of patients had R0-resection, 25% major morbidity, 21% an ISGPS grade B/C pancreatic fistula, and 16% mortality. In total, 82% received (neo-)adjuvant chemotherapy and median overall survival in 62 patients with pancreatic ductal adenocarcinoma patients was 18 months (CI 10-37). We observed no impact of PHAE on ischemic complications.
conclusionsDP-CAR combined with chemotherapy for locally advanced pancreatic cancer is associated with acceptable overall survival. The 90-day mortality is too high and should be reduced. Future studies should investigate to what extent increasing surgical volume or better patient selection can improve outcomes.
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