Evidence map›Paper›PMID 29532243›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2018

Healthy Bones Study: can a prescription coupled with education improve bone health for patients receiving androgen deprivation therapy?-a before/after study.

Derek S Tsang, Jennifer M Jones, Osai Samadi, Suhayb Shah, Nicholas Mitsakakis, Charles N Catton, William Jeon, Joshua To, Henriette Breunis, Shabbir M H Alibhai

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01973673 (Healthy Bones Study), which is not on this map. Cited by 7 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01973673 nacompletednot on this map

Healthy Bones Study: An Intervention to Improve Healthy Bone Behaviours in Prostate Cancer Patients on Androgen Deprivation Therapy (ADT)

TypeinterventionalSponsorUniversity Health Network, TorontoRan2013 to 2017Enrolled200ConditionsLocally Advanced Malignant NeoplasmArmsBone health educational materials
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Exercise Therapy and Radiation Therapy for Cancer: A Systematic Review.International journal of radiation oncology, biology, physics · 2021
    Pooled it
  3. Physical exercise for bone health in men with prostate cancer receiving androgen deprivation therapy: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Derek S TsangRadiation Medicine Program, Princess Margaret Cancer Centre, University Health Network and University of Toronto, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada.
Jennifer M JonesCancer Survivorship Program (ELLICSR), Princess Margaret Cancer Centre, University Health Network, 585 University Avenue, Toronto, Ontario, M5G 2C4, Canada.
Osai SamadiDepartment of Medicine, University Health Network and University of Toronto, 200 Elizabeth St., Toronto, Ontario, M5G 2C4, Canada.
Suhayb ShahCancer Survivorship Program (ELLICSR), Princess Margaret Cancer Centre, University Health Network, 585 University Avenue, Toronto, Ontario, M5G 2C4, Canada.
Nicholas MitsakakisBiostatistics Research Unit, University Health Network; Institute of Health Policy, Management and Evaluation, University of Toronto, 155 College St., Toronto, Ontario, M5T 3M6, Canada.
Charles N CattonRadiation Medicine Program, Princess Margaret Cancer Centre, University Health Network and University of Toronto, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada.
William JeonCancer Survivorship Program (ELLICSR), Princess Margaret Cancer Centre, University Health Network, 585 University Avenue, Toronto, Ontario, M5G 2C4, Canada.
Joshua ToCancer Survivorship Program (ELLICSR), Princess Margaret Cancer Centre, University Health Network, 585 University Avenue, Toronto, Ontario, M5G 2C4, Canada.
Henriette BreunisDepartment of Medicine, University Health Network and University of Toronto, 200 Elizabeth St., Toronto, Ontario, M5G 2C4, Canada.
Shabbir M H AlibhaiDepartment of Medicine, University Health Network and University of Toronto, 200 Elizabeth St., Toronto, Ontario, M5G 2C4, Canada. shabbir.alibhai@uhn.ca.

Funding

Canadian Association of Radiation Oncology ACURA
6 · The paper itself

Abstract

purposeTo evaluate the ability of a multimodal patient education initiative to improve adherence to healthy bone behaviors (HBBs) in men with prostate cancer receiving androgen deprivation therapy (ADT).

methodsThis was a pilot prospective, single-site, before-and-after clinical trial. The control arm (n = 51) received routine care. The intervention arm (n = 52) received multimodal HBB education which included a healthy bones prescription (BoneRx), focused face-to-face education with an oncology nurse or physician, and customized educational materials. The primary endpoints were feasibility of study methods and self-reported adherence to HBBs (vitamin D intake ≥ 1000 IU/day, calcium intake 1000-1500 mg/day, and exercise ≥ 150 min/week) at 3-month follow-up. Secondary endpoints included receipt of bone mineral density (BMD) testing.

resultsPatients were satisfied with the study intervention, found educational materials easy to understand, and felt that it increased their knowledge about osteoporosis. Although the intervention appeared to be associated with trends toward improved levels of vitamin D intake (adjusted odds ratio [OR] 1.8, 95% confidence interval [CI] 0.74-4.5), calcium intake (OR 1.5, 95% CI 0.63-3.4), and exercise (OR 1.7, 0.75-3.9) as compared to the control arm, none of these were statistically significant. Patients who received the study intervention were more likely to receive BMD testing (OR 3.3, 95% CI 1.3-8.8).

conclusionsAlthough a brief, tailored educational intervention was feasible to implement and improve BMD test utilization, it did not increase HBB participation. Larger, well-designed trials are needed to clarify the effect of patient education interventions on HBB adherence.

trial registrationClinicalTrials.gov ( NCT01973673 ).

Indexed as

AgedAged, 80 and overAndrogen AntagonistsBone and BonesHumansMaleMiddle AgedOsteoporosisPatient Education as TopicPilot ProjectsProspective StudiesAndrogen AntagonistsAndrogen deprivation therapyCalciumOsteoporosisPatient educationProstatic neoplasmsVitamin D

Identifiers

PMID29532243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.