ArticlePediatric nephrology (Berlin, Germany)2018
Predictive ability of NGAL in identifying urinary tract infection in children with neurogenic bladders.
Article in Pediatric nephrology (Berlin, Germany), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluation of diagnostic accuracy of urine neutrophil gelatinase-associated lipocalin in patients with symptoms of urinary tract infections: a meta-analysis.Frontiers in pediatrics · 2024Pooled it
- Diagnostic Accuracy of Urine Microbial Diversity and Urine Neutrophil Gelatinase-Associated Lipocalin for the Diagnosis of Urinary Tract Infections in Children with Spina Bifida.The Journal of pediatrics · 2026Article
- Diagnostic evaluation and treatment of UTIs in children with neurogenic bladder.Journal of pediatric urology · 2026Article
- Differential Effects of Uropathogenic and Non-UropathogenicResearch and reports in urology · 2026Article
- SCI Model Systems Complicated Urinary Tract Infection (cUTI) Guidelines: International Consensus on cUTI Likelihood Based on Symptoms.Topics in spinal cord injury rehabilitation · 2025Article
- Biomarkers for urinary tract infection: present and future perspectives.Pediatric nephrology (Berlin, Germany) · 2024Review
- A Multimodal Fuzzy Approach in Evaluating Pediatric Chronic Kidney Disease Using Kidney Biomarkers.Diagnostics (Basel, Switzerland) · 2024Article
- Intercalated cell function, kidney innate immunity, and urinary tract infections.Pflugers Archiv : European journal of physiology · 2024Review
- Evaluation of Urinary L-FABP as a Tubular Damage Marker in Pediatric Neurogenic Bladder-A Pilot Study.Journal of clinical medicine · 2024Article
- Urine Biomarkers in the Management of Adult Neurogenic Lower Urinary Tract Dysfunction: A Systematic Review.Diagnostics (Basel, Switzerland) · 2023Review
- Innate Bacteriostatic Mechanisms Defend the Urinary Tract.Annual review of physiology · 2022Review
- The association between urine neutrophil gelatinase-associated lipocalin and UTI in people with neurogenic lower urinary tract dysfunction.Spinal cord · 2021Article
- Are Tubular Injury Markers NGAL and KIM-1 Useful in Pediatric Neurogenic Bladder?Journal of clinical medicine · 2021Article
- Urine neutrophil gelatinase-associated lipocalin in girls with recurrent urinary tract infections.Pediatric nephrology (Berlin, Germany) · 2020Article
- A cross-sectional analysis of the urine microbiome of children with neuropathic bladders.Journal of pediatric urology · 2020Article
- NGAL protects in nasopharyngeal carcinoma by inducing apoptosis and blocking epithelial-mesenchymal transition.Oncology letters · 2020Article
- Symptom- and urinalysis-based approach to diagnosing urinary tract infections in children with neuropathic bladders.Pediatric nephrology (Berlin, Germany) · 2020Article
- Biomarkers in urinary tract infections - which ones are suitable for diagnostics and follow-up?GMS infectious diseases · 2020Review
- Discriminatory Precision of Neutrophil Gelatinase-Associated Lipocalin in Detection of Urinary Tract Infection in Children: a Systematic Review and Meta-Analysis.Archives of academic emergency medicine · 2020Review
- Aptamer based proteomic pilot study reveals a urine signature indicative of pediatric urinary tract infections.PloS one · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundDistinguishing between urinary tract infection (UTI) and colonization (UTC) in patients with neurogenic bladders who require clean intermittent catheterization (CIC) is difficult. Urinary neutrophil gelatinase-associated lipocalin concentrations (uNGAL) are increased in UTIs. Our objective was to determine the predictive accuracy of uNGAL for UTI in CIC-dependent children.
methodsCross-sectional study of CIC-dependent patients from August, 2015 to November, 2016. UTI was defined as (1) growth of ≥ 50,000 cfu/mL of a uropathogen, (2) > 10 urinary white blood cells/hpf, and (3) ≥ 2 of the following: temperature > 38 °C, abdominal pain, back pain, worsened incontinence, pain with catheterization, or malodorous/cloudy urine. Positive urine cultures that did not meet these criteria were grouped as UTC, and negative cultures were grouped as no growth.
resultsTwo hundred one patients were included (no growth = 100, UTC = 77, UTI = 24). Median (interquartile range) uNGAL was higher in the UTI group (UTI 1361 (931, 2516) μg/g creatinine, UTC 246 (106, 548) μg/g creatinine, no growth 36 (11, 179) μg/g creatinine, p < 0.01 for all comparisons). The area under the ROC curve for uNGAL for UTI versus no UTI was 0.89, 95% CI (0.80-0.98).
conclusionuNGAL is elevated in CIC-dependent children with UTI compared to those with negative cultures and those with UTC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.