Evidence map›Paper›PMID 29532222›Full record

ArticleWorld journal of urology2018

Comparison of functional outcomes of robotic and open partial nephrectomy in patients with pre-existing chronic kidney disease: a multicenter study.

Zachary A Hamilton, Robert G Uzzo, Alessandro Larcher, Brian R Lane, Benjamin Ristau, Umberto Capitanio, Stephen Ryan, Sumi Dey, Andres Correa, Madhumitha Reddy and 7 more

Abstract readComparative StudyMulticenter Study
PubMed Publisher
In one paragraph

Article in World journal of urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Endovascular control during partial nephrectomy in a renal allograft.Indian journal of urology : IJU : journal of the Urological Society of India
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 2 countries.

Zachary A HamiltonDepartment of Urology, UC San Diego Health System, Moores UCSD Cancer Center, 3855 Health Sciences Drive, La Jolla, CA, 93093-0987, USA.
Robert G UzzoDepartment of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Alessandro LarcherDivision of Experimental Oncology, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Brian R LaneDivision of Urology, Spectrum Health, Grand Rapids, MI, USA.
Benjamin RistauDepartment of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Umberto CapitanioDivision of Experimental Oncology, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Stephen RyanDepartment of Urology, UC San Diego Health System, Moores UCSD Cancer Center, 3855 Health Sciences Drive, La Jolla, CA, 93093-0987, USA.
Sumi DeyDivision of Experimental Oncology, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Andres CorreaDepartment of Urologic Oncology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Madhumitha ReddyDepartment of Urology, UC San Diego Health System, Moores UCSD Cancer Center, 3855 Health Sciences Drive, La Jolla, CA, 93093-0987, USA.
James A ProudfootClinical and Translational Research Institute, UC San Diego, La Jolla, CA, USA.
Ryan NasseriDepartment of Urology, UC San Diego Health System, Moores UCSD Cancer Center, 3855 Health Sciences Drive, La Jolla, CA, 93093-0987, USA.
Kendrick YimDepartment of Urology, UC San Diego Health System, Moores UCSD Cancer Center, 3855 Health Sciences Drive, La Jolla, CA, 93093-0987, USA.
Sabrina NoyesDivision of Experimental Oncology, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Ahmet BindayiDepartment of Urology, UC San Diego Health System, Moores UCSD Cancer Center, 3855 Health Sciences Drive, La Jolla, CA, 93093-0987, USA.
Francesco MontorsiDivision of Experimental Oncology, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Ithaar H DerweeshDepartment of Urology, UC San Diego Health System, Moores UCSD Cancer Center, 3855 Health Sciences Drive, La Jolla, CA, 93093-0987, USA. iderweesh@gmail.com.
Moores Cancer CenterFox Chase Cancer Center · USIstituto di Ricovero e Cura a Carattere Scientifico San RaffaeleUC San Diego Health System · USVita-Salute San Raffaele University · ITIstituti di Ricovero e Cura a Carattere Scientifico · ITSpectrum Health · USUniversity of California, San Diego · US

Funding

National Institutes of Health UL1TR000100National Institutes of Health UL1TR001442
6 · The paper itself

Abstract

backgroundWe compared renal functional outcomes of robotic (RPN) and open partial nephrectomy (OPN) in patients with chronic kidney disease (CKD), a definite indication for nephron-sparing surgery.

methodsA multicenter retrospective analysis of OPN and RPN in patients with baseline ≥ CKD Stage III [estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m

results728 patients (426 OPN, 302 RPN, mean follow-up 33.3 months) were analyzed. Similar RENAL score distribution (p = 0.148) was noted between groups. RPN had lower median estimated blood loss (p < 0.001), and hospital stay (3 vs. 5 days, p < 0.001). Median ischemia time (OPN 23.7 vs. RPN 21.5 min, p = 0.089), positive margin (p = 0.256), transfusion (p = 0.166), and 30-day complications (p = 0.208) were similar. For OPN vs. RPN, mean ΔeGFR demonstrated no significant difference for simple (0.5 vs. 0.3, p = 0.328), intermediate (2.1 vs. 2.1, p = 0.384), and complex (4.9 vs. 6.1, p = 0.108). Cox regression analysis demonstrated that decreasing preoperative eGFR (OR 1.10, p = 0.001) and complex RENAL score (OR 5.61, p = 0.03) were independent predictors for eGFR decline > 50%. Kaplan-Meier analysis demonstrated 5-year freedom from eGFR decline > 50% of 88.6% for OPN and 88.3% for RPN (p = 0.724).

conclusionsRPN and OPN demonstrated similar renal functional outcomes when stratified by tumor complexity group. Increasing tumor age and tumor complexity were primary drivers associated with functional decline. RPN provides similar renal functional outcomes to OPN in appropriately selected patients.

Indexed as

Renal Insufficiency, ChronicRobotic Surgical ProceduresAgedFemaleGlomerular Filtration RateHumansKidney NeoplasmsMaleNephrectomyRetrospective StudiesTreatment OutcomeCarcinoma, Renal cellChronic renal insufficiencyEstimated glomerular filtration rateHemodialysisPartial nephrectomyRobotic-assisted laparoscopy

Identifiers

PMID29532222
OpenAlexW2791241370

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.