ArticleBMJ open respiratory research2018
Symptom severity and its effect on health-related quality of life over time in patients with pulmonary hypertension: a multisite longitudinal cohort study.
Article in BMJ open respiratory research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Apabetalone for Pulmonary Arterial Hypertension: a Pilot Study
Development and Pilot Randomised Controlled Trial of a Self-help Sleep Hygiene Intervention to Help Individuals With Pulmonary Hypertension
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of psychological interventions in adults with pulmonary hypertension: Is the evidence-base disproportionate to the problem?The clinical respiratory journal · 2023Pooled it
- Adults' experiences of living with pulmonary hypertension: a thematic synthesis of qualitative studies.BMJ open · 2020Pooled it
- A randomized controlled trial of self-help cognitive behavioural therapy for depression in adults with pulmonary hypertension.British journal of health psychology · 2025Trial
- Safety and efficacy of RT234 vardenafil inhalation powder on exercise parameters in pulmonary arterial hypertension: phase II, dose-escalation study design.Respiratory research · 2022Trial
- Clinical Utility of the PHQ-2 and GAD-2 in Pulmonary Hypertension.Pulmonary circulation · 2026Article
- Real-World Treatment Patterns and Burden of Chronic Thromboembolic Pulmonary Hypertension Patients across Consultation Settings in the USA.Pulmonary therapy · 2026Article
- The Pulmonary Hypertension Global Patient Survey: Physical and Psychosocial Impacts on Health-Related Quality of Life.Pulmonary circulation · 2026Article
- Mediating Effects of Fear of Movement and Self-Efficacy Between Illness Perception and Health-Related Quality of Life in Pulmonary Hypertension.Psychology research and behavior management · 2026Article
- The Pulmonary Hypertension Global Patient Survey: Groups 2 and 3.Pulmonary circulation · 2026Article
- Digital endpoints in clinical trials: emerging themes from a multi-stakeholder Knowledge Exchange event.Trials · 2024Article
- Interactions between Cognitive, Affective, and Respiratory Profiles in Chronic Respiratory Disorders: A Cluster Analysis Approach.Diagnostics (Basel, Switzerland) · 2024Article
- Exploratory and confirmatory factor analysis of emPHasis-10: The health-related quality-of-life measure in pulmonary hypertension.Pulmonary circulation · 2024Article
- The one-minute sit-to-stand-test performance is associated with health-related quality of life in patients with pulmonary hypertension.PloS one · 2024Article
- The Role of Cardiac MRI in Pulmonary Hypertension- Is it Still an Underutilized Tool.The open respiratory medicine journal · 2024Review
- Exploration of physical activity knowledge, preferences and support needs among pulmonary hypertension patients.PloS one · 2023Article
- Cognitive and behavioral processes predict anxiety and depression in patients with pulmonary hypertension.Pulmonary circulation · 2022Article
- EmPHasis-10 Health-Related Quality of Life and Exercise Capacity in Chronic Thromboembolic Pulmonary Hypertension After Balloon Angioplasty.Journal of the American Heart Association · 2022Article
- Article
- Examining the impact of pulmonary hypertension on nonprofessional caregivers: A mixed-methods systematic review.Pulmonary circulation · 2022Review
- Self-help cognitive behavioural therapy for anxiety in pulmonary hypertension: pilot randomised controlled trial.ERJ open research · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this cohort study was to examine health-related quality of life (HRQoL) and symptomatology in patients with pulmonary hypertension (PH) and explore factors that influence its evolution over time.
methodsA prospective longitudinal multisite cohort study. Participants were recruited from specialist UK PH centres and completed a questionnaire pack at baseline, 6, 12 and 18 months to assess HRQoL (emPHasis-10), dyspnoea, fatigue, sleep, anxiety and depression.
results185 patients entered the study at baseline and 126 (68%) completed month 18. At baseline, patients had significant impairment of HRQoL, anxiety, depression, dyspnoea and severe fatigue. No significant changes, apart from a reduction in the Hospital Anxiety and Depression Scale-Anxiety score (P=0.04), were observed over 18 months. Depression and dyspnoea were predictors of HRQoL (P=0.002 and P=0.03, respectively). Oxygen use was also associated with diminished HRQoL and increased symptom severity.
conclusionPatients with PH experience high levels of symptom severity and the negative impact on HRQoL was unchanged over time. The use of oxygen therapy, in particular, was associated with a significant impact on HRQoL. Further study of factors impacting HRQoL and interventions that target a combination of physiological and psychosocial consequences of living with PH are needed.
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