Evidence map›Paper›PMID 29531645›Full record

ArticleInternational journal of organ transplantation medicine2018

mRNA Expression of Interferon Regulatory Factors during Acute Rejection of Liver Transplants in Patients with Autoimmune Hepatitis.

M Nasiri, B Geramizadeh, S H Nabavizadeh, S A Male-Hosseini, M H Karimi, I Saadat

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of organ transplantation medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

M NasiriDepartment of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
B GeramizadehTransplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
S H NabavizadehCellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.
S A Male-HosseiniTransplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
M H KarimiTransplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
I SaadatDepartment of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
Shiraz University of Medical Sciences · IRShiraz University · IRYasuj University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInterferon regulatory factors (IRFs) can play a critical role in the regulation of many facets of innate and adaptive immune responses through transcriptional activation of type I interferons, other proinflammatory cytokines, and chemokines. However, their roles in transplantation immunity still remain to be elucidated.

objectiveTo evaluate the time course of mRNA expression of all 9 members of IRFs family of transcription factors during liver allograft acute rejection.

methodsBlood samples of 19 patients with autoimmune hepatitis receiving liver transplants were collected on days 1, 3, 5, and 7 post-transplantation. The patients were followed for 6 months after transplantation and divided into two groups of acute rejection (AR) (n=4) and non-acute rejection (non-AR) (n=15).

resultsAll of the studied transcription factors were down-regulated in AR-group on days 3, 5, and 7 post-transplantation compared to non-AR group. The mean±SEM IRF5 on day 7 post-transplantation was significantly (p=0.005) lower in AR-group than in non-AR group (0.7±0.21

conclusionIRF5 may have an important role during the acute rejection of liver transplants.

Indexed as

autoimmuneGraft rejectionHepatitisInterferon regulatory factorLiver transplantationMessengerRNAToll like receptortranscription factors

Identifiers

PMID29531645
PMCPMC5839628
OpenAlexW2813079382

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.