ArticleOpen access Macedonian journal of medical sciences2018
Increasing Atherosclerosis in Streptozotocin-Induced Diabetes into Four Groups of Mice.
Article in Open access Macedonian journal of medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 4 citations in OpenAlex.
- Combating atherosclerosis with targeted Diosmin nanoparticles-treated experimental diabetes.Investigational new drugs · 2020Article
- Role of Mitochondrial Stress Protein HSP60 in Diabetes-Induced Neuroinflammation.Mediators of inflammation · 2020Review
- General Study and Gene Expression Profiling of Endotheliocytes Cultivated on Electrospun Materials.Materials (Basel, Switzerland) · 2019Article
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4 authors at 1 institution in 1 country.
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Abstract
aimTo study the protective effect of medicines on the formation of atherosclerosis in mice, it is needed to conduct the study in mice which is not genetically diabetic mice induced by streptozotocin (STZ) to produce hyperglycemia and atherosclerosis, compared with mice treated by yolk or its combination. MATERIAL AND
methodsFifty-six mice, Double Deutch Webster strain, male, receive 10 weeks, 20 - 30 gr bodyweight were divided into 4 groups (n = 14) i.e. control (do not received any agents), STZ (45 mg/kg/BW was injected intraperitoneally for 5 days), yolk (0.2 cc orally daily for 6 weeks), and combination of STZ and yolk (. STZ: 45 mg/kg/BW intraperitoneally add 0.2 cc yolk orally). All animals were executed in the 42nd day. Then, the aorta of the mice's heart tissue was histopathology examined. Blood glucose and cholesterol levels were determined every week.
resultsHyperglycemia occurred in mice induced by STZ injection with the highest BGL (521.8 ± 48.2 mg/dl; 188.4%) in the 4th-week observation; after that BGL decrease. We found that, except the control, all treatment groups with STZ, egg yolk, and combination underwent atherosclerosis.
conclusionThe present study was able to demonstrate the occurrence of atherosclerosis in mice treated by STZ accompanied with increasing blood glucose and cholesterol level.
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