ArticleOpen access Macedonian journal of medical sciences2018
Polymerase Chain Reaction-Restriction Fragment Length Polymorphism as a Confirmatory Test for Onychomycosis.
Article in Open access Macedonian journal of medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 18 citations in OpenAlex.
- Genetic relatedness and diversity of Capillaria species infecting bayad (Bagrus bajad) in upper Egypt.BMC veterinary research · 2024Article
- Epidemiology and Diagnostic Perspectives of Dermatophytoses.Journal of fungi (Basel, Switzerland) · 2020Review
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3 authors at 1 institution in 1 country.
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Abstract
backgroundOnychomycosis is a fungal infection of one or more units of the nail caused by dermatophytes, or mould and nondermatophytes yeast. Investigations are needed to establish the diagnosis of onychomycosis before starting treatment. Several investigations methods for diagnosing onychomycosis are microscopic examination with 20% KOH, fungal culture, histopathology examination with PAS staining (Periodic acid Schiff) and PCR (Polymerase Chain Reaction). Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) is a method after PCR amplification allowing more specific results.
aimTo determine the diagnostic value of PCR - RFLP in the diagnosis of onychomycosis using fungal culture as the gold standard and to find out the majority fungal species that cause onychomycosis.
methodsThis study is a diagnostic test for the diagnosis of onychomycosis by using culture as the gold standard. SUBJECTS: Thirty - five patients suspected of having onychomycosis from history and dermatological examination.
resultsPCR - RFLP in the diagnosis of onychomycosis has a sensitivity of 85.71%, specificity of 28.57%, positive predictive value (PPV) of 82.76% and negative predictive value (NPV) of 33.33%. The positive and negative likelihood ratios are 1.20 and 0.5 with an accuracy of 74.29%.
conclusionsPCR - RFLP may be considered for a faster and more accurate alternative examination in the diagnosis of onychomycosis.
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