ArticleNature chemistry2018
Dynamic protein assembly by programmable DNA strand displacement.
Article in Nature chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Cell-Membrane-Anchored DNA Nanoplatform for Programming Cellular Interactions.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Live-Cell Imaging of miRNAs with the Combination of CHA and HCR Techniques.Methods in molecular biology (Clifton, N.J.) · 2025Article
- DNA-Regulated Multi-Protein Complement Control.Journal of the American Chemical Society · 2024Article
- Engineering conditional protein-protein interactions for dynamic cellular control.Biotechnology advances · 2024Review
- Engineering Hepatitis B Virus (HBV) Protein Particles for Therapeutic Delivery.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Pursuing excitonic energy transfer with programmable DNA-based optical breadboards.Chemical Society reviews · 2023Review
- A Semisynthetic Bioluminescence Sensor for Ratiometric Imaging of Metal Ions In Vivo Using DNAzymes Conjugated to An Engineered Nano-Luciferase.Angewandte Chemie (International ed. in English) · 2023Article
- Preparation, applications, and challenges of functional DNA nanomaterials.Nano research · 2023Review
- Competitive SNP-LAMP probes for rapid and robust single-nucleotide polymorphism detection.Cell reports methods · 2022Article
- Dynamic modulation of enzyme activity by synthetic CRISPR-Cas6 endonucleases.Nature chemical biology · 2022Article
- DNA-Mediated Protein Shuttling between Coacervate-Based Artificial Cells.Angewandte Chemie (International ed. in English) · 2022Article
- Strategies for Multienzyme Assemblies.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Protein Assembly by Design.Chemical reviews · 2021Review
- Dual Catalytic Hairpin Assembly-Based Automatic Molecule Machine for Amplified Detection of Auxin Response Factor-Targeted MicroRNA-160.Molecules (Basel, Switzerland) · 2021Article
- Review
- A Modular, Dynamic, DNA-Based Platform for Regulating Cargo Distribution and Transport between Lipid Domains.Nano letters · 2021Article
- Fuel-Driven Transient DNA Strand Displacement Circuitry with Self-Resetting Function.Journal of the American Chemical Society · 2020Article
- Nanoparticles for Manipulation of the Developmental Wnt, Hedgehog, and Notch Signaling Pathways in Cancer.Annals of biomedical engineering · 2020Review
- DNA Microsystems for Biodiagnosis.Micromachines · 2020Review
- Constructing Controllable Logic Circuits Based on DNAzyme Activity.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inspired by the remarkable ability of natural protein switches to sense and respond to a wide range of environmental queues, here we report a strategy to engineer synthetic protein switches by using DNA strand displacement to dynamically organize proteins with highly diverse and complex logic gate architectures. We show that DNA strand displacement can be used to dynamically control the spatial proximity and the corresponding fluorescence resonance energy transfer between two fluorescent proteins. Performing Boolean logic operations enabled the explicit control of protein proximity using multi-input, reversible and amplification architectures. We further demonstrate the power of this technology beyond sensing by achieving dynamic control of an enzyme cascade. Finally, we establish the utility of the approach as a synthetic computing platform that drives the dynamic reconstitution of a split enzyme for targeted prodrug activation based on the sensing of cancer-specific miRNAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.