Evidence map›Paper›PMID 29531354›Full record

SynthesisNature genetics2018

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.

Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten-Jacobs, Anne-Katrin Giese, Sander W van der Laan, Solveig Gretarsdottir and 176 more

Erratum issuedAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 957 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
957citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

957 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Does illicit drug use increase stroke risk? A systematic review, meta-analyses, and Mendelian randomization analysis.International journal of stroke : official journal of the International Stroke Society · 2026
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  11. Multi-Omics Genome-Wide to Explore the Formation and Development Targets for Intracranial Aneurysms.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
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  20. Observational

897 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

186 authors.

Rainer Malik *Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
Ganesh Chauhan *Centre for Brain Research, Indian Institute of Science, Bangalore, India.
Matthew Traylor *INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France.ORCID http://orcid.org/0000-0001-6624-8621
Muralidharan Sargurupremraj *Stroke Research Group, Division of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Yukinori Okada *Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0002-0311-8472
Aniket MishraStroke Research Group, Division of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Loes Rutten-JacobsINSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France.ORCID http://orcid.org/0000-0003-3223-885X
Anne-Katrin GieseDepartment of Neurology, Massachusetts General Hospital (MGH), Harvard Medical School, Boston, MA, USA.
Sander W van der LaanLaboratory of Experimental Cardiology, Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0001-6888-1404
Solveig GretarsdottirdeCODE genetics/AMGEN Inc., Reykjavik, Iceland.
Christopher D AndersonCenter for Genomic Medicine, MGH, Boston, MA, USA.
Michael ChongPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Hieab H H AdamsDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-3687-2508
Tetsuro AgoDepartment of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Peter AlmgrenDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID http://orcid.org/0000-0002-0473-0241
Philippe AmouyelINSERM, Institut Pasteur de Lille, LabEx DISTALZ-UMR1167, Risk Factors and Molecular Determinants of Aging-Related Diseases, Université Lille, Lille, France.ORCID http://orcid.org/0000-0001-9088-234X
Hakan AyJ. Philip Kistler Stroke Research Center, Department of Neurology, MGH, Boston, MA, USA.
Traci M BartzCardiovascular Health Research Unit, Departments of Biostatistics and Medicine, University of Washington, Seattle, WA, USA.
Oscar R BenaventeDivision of Neurology, Faculty of Medicine, Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada.
Steve BevanSchool of Life Science, University of Lincoln, Lincoln, UK.
Giorgio B BoncoraglioDepartment of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy.
Robert D BrownDepartment of Neurology, Mayo Clinic Rochester, Rochester, MN, USA.
Adam S ButterworthMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Caty CarreraNeurovascular Research Laboratory, Vall d'Hebron Institut of Research, Neurology and Medicine Departments-Universitat Autònoma de Barcelona, Vall d'Hebrón Hospital, Barcelona, Spain.
Cara L CartyChildren's Research Institute, Children's National Medical Center, Washington, DC, USA.
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Wei-Min ChenCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
John W ColeDepartment of Neurology, University of Maryland School of Medicine and Baltimore VAMC, Baltimore, MD, USA.
Adolfo CorreaDepartments of Medicine, Pediatrics and Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA.ORCID http://orcid.org/0000-0002-9501-600X
Ioana CotlarciucInstitute of Cardiovascular Research, Royal Holloway University of London, London, UK, and Ashford and St Peters Hospital, Surrey, UK.
Carlos CruchagaDepartment of Psychiatry, Hope Center Program on Protein Aggregation and Neurodegeneration (HPAN), Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0276-2899
John DaneshMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Paul I W de BakkerDepartment of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
Anita L DeStefanoBoston University School of Public Health, Boston, MA, USA.
Marcel den HoedDepartment of Immunology, Genetics and Pathology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0001-8081-428X
Qing DuanDepartment of Genetics, University of North Carolina, Chapel Hill, NC, USA.
Stefan T EngelterDepartment of Neurology and Stroke Center, Basel University Hospital, Basel, Switzerland.
Guido J FalconeDepartment of Neurology, Yale University School of Medicine, New Haven, CT, USA.
Rebecca F GottesmanDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Raji P GrewalNeuroscience Institute, SF Medical Center, Trenton, NJ, USA.
Vilmundur GudnasonIcelandic Heart Association Research Institute, Kopavogur, Iceland.
Stefan GustafssonDepartment of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0001-5894-0351
Jeffrey HaesslerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Tamara B HarrisLaboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Ahamad HassanDepartment of Neurology, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Aki S HavulinnaNational Institute for Health and Welfare, Helsinki, Finland.ORCID http://orcid.org/0000-0002-4787-8959
Susan R HeckbertDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Elizabeth G HollidayPublic Health Stream, Hunter Medical Research Institute, New Lambton, New South Wales, Australia.
George HowardSchool of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Fang-Chi HsuDepartment of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Hyacinth I HyacinthAflac Cancer and Blood Disorder Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
M Arfan IkramDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Erik IngelssonDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Marguerite R IrvinEpidemiology, School of Public Health, University of Alabama at Birmingham, Birmingham, AL, USA.
Xueqiu JianBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Jordi Jiménez-CondeNeurovascular Research Group (NEUVAS), Neurology Department, Institut Hospital del Mar d'Investigació Mèdica, Universitat Autònoma de Barcelona, Barcelona, Spain.
Julie A JohnsonDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, College of Pharmacy, Gainesville, FL, USA.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-3246-8359
Masahiro KanaiLaboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0001-5165-4408
Keith L KeeneDepartment of Biology, East Carolina University, Greenville, NC, USA.
Brett M KisselaUniversity of Cincinnati College of Medicine, Cincinnati, OH, USA.
Dawn O KleindorferUniversity of Cincinnati College of Medicine, Cincinnati, OH, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Michiaki KuboRIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Leslie A LangeDepartment of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
Carl D LangefeldCenter for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK.
Lenore J LaunerIntramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Jin-Moo LeeDepartment of Neurology, Radiology, and Biomedical Engineering, Washington University School of Medicine, St. Louis, MO, USA.
Robin LemmensDepartment of Neurosciences, Experimental Neurology, KU Leuven-University of Leuven, Leuven, Belgium.
Didier LeysINSERM U 1171, CHU Lille, Université Lille, Lille, France.
Cathryn M LewisDepartment of Medical and Molecular Genetics, King's College London, London, UK.ORCID http://orcid.org/0000-0002-8249-8476
Wei-Yu LinMRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-9267-7988
Arne G LindgrenDepartment of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden.
Erik LorentzenBioinformatics Core Facility, University of Gothenburg, Gothenburg, Sweden.
Patrik K MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-7315-7899
Jane MaguireUniversity of Technology Sydney, Faculty of Health, Ultimo, New South Wales, Australia.
Ani ManichaikulCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Patrick F McArdleDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
James F MeschiaDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Braxton D MitchellDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Thomas H MosleyDivision of Geriatrics, School of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
Michael A NallsLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Toshiharu NinomiyaDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Martin J O'DonnellPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Sara L PulitDepartment of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0002-2502-3669
Kristiina RannikmäeUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Alexander P ReinerDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Kathryn M RexrodeDepartment of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Stephen S RichCenter for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Natalia S RostDepartment of Neurology, Massachusetts General Hospital (MGH), Harvard Medical School, Boston, MA, USA.
Peter M RothwellNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Tatjana RundekDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Ralph L SaccoDepartment of Neurology, Miller School of Medicine, University of Miami, Miami, FL, USA.
Saori SakaueDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.
Michele M SaleCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Veikko SalomaaNational Institute for Health and Welfare, Helsinki, Finland.
Bishwa R SapkotaDepartment of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Reinhold SchmidtDepartment of Neurology, Medical University of Graz, Graz, Austria.
Carsten O SchmidtInstitute for Community Medicine, SHIP-KEF, University Medicine Greifswald, Greifswald, Germany.
Ulf SchminkeDepartment of Neurology, University Medicine Greifswald, Greifswald, Germany.
Pankaj SharmaInstitute of Cardiovascular Research, Royal Holloway University of London, London, UK, and Ashford and St Peters Hospital, Surrey, UK.
Agnieszka SlowikDepartment of Neurology, Jagiellonian University, Krakow, Poland.
Cathie L M SudlowUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Christian TanislavDepartment of Neurology, Justus Liebig University, Giessen, Germany.
Turgut TatlisumakDepartment of Clinical Neurosciences/Neurology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
Vincent N S ThijsStroke Division, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Heidelberg, Victoria, Australia.
Gudmar ThorleifssondeCODE genetics/AMGEN Inc., Reykjavik, Iceland.
Unnur ThorsteinsdottirdeCODE genetics/AMGEN Inc., Reykjavik, Iceland.
Steffen TiedtInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
Stella TrompetDepartment of Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Christophe TzourioDepartment of Neurology, Institute for Neurodegenerative Disease, Bordeaux University Hospital, Bordeaux, France.
Cornelia M van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Matthew WaltersSchool of Medicine, Dentistry and Nursing at the University of Glasgow, Glasgow, UK.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge, UK.
Sylvia Wassertheil-SmollerDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
Kerri L WigginsCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2749-1279
Qiong YangBoston University School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3658-1375
Salim YusufPopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
AFGen Consortium
Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium
International Genomics of Blood Pressure (iGEN-BP) Consortium
INVENT Consortium
STARNET
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Tomi PastinenDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada.
Arno RuusaleppDepartment of Pathophysiology, Institute of Biomedicine and Translation Medicine, University of Tartu, Tartu, Estonia.
Eric E SchadtDepartment of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-7892-8808
Simon KoplevDepartment of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8586-5614
Johan L M BjörkegrenDepartment of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Veronica CodoniUPMC Univ. Paris 06, INSERM, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Sorbonne Universités, Paris, France.
Mete CivelekCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.ORCID http://orcid.org/0000-0002-8141-0284
Nicholas L SmithDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
David A TrégouëtUPMC Univ. Paris 06, INSERM, UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Sorbonne Universités, Paris, France.ORCID http://orcid.org/0000-0001-9084-7800
Ingrid E ChristophersenProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6141-4712
Carolina RoselliProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5267-6756
Steven A LubitzProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Patrick T EllinorProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2067-0533
E Shyong TaiSaw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
Jaspal S KoonerNational Heart and Lung Institute, Imperial College London, London, UK.
Norihiro KatoDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
Jiang HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.
Pim van der HarstDepartment of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-2713-686X
Paul ElliottMRC-PHE Centre for Environment and Health, School of Public Health, Department of Epidemiology and Biostatistics and the NIHR Imperial Biomedical Research Centre, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-7511-5684
John C ChambersDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Fumihiko TakeuchiDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.ORCID http://orcid.org/0000-0003-3185-5661
Andrew D JohnsonFramingham Heart Study, Framingham, MA, USA.
BioBank Japan Cooperative Hospital Group
COMPASS Consortium
EPIC-CVD Consortium
EPIC-InterAct Consortium
International Stroke Genetics Consortium (ISGC)
METASTROKE Consortium
Neurology Working Group of the CHARGE Consortium
NINDS Stroke Genetics Network (SiGN)
UK Young Lacunar DNA Study
MEGASTROKE Consortium
Dharambir K SangheraDepartment of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
Olle MelanderDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Christina JernDepartment of Pathology and Genetics, Institute of Biomedicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.ORCID http://orcid.org/0000-0002-7531-2354
Daniel StrbianDepartment of Neurology, Helsinki University Hospital, Helsinki, Finland.
Israel Fernandez-CadenasNeurovascular Research Laboratory, Vall d'Hebron Institut of Research, Neurology and Medicine Departments-Universitat Autònoma de Barcelona, Vall d'Hebrón Hospital, Barcelona, Spain.
W T LongstrethDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Arndt RolfsAlbrecht Kossel Institute, University Clinic of Rostock, Rostock, Germany.
Jun HataDepartment of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Daniel WooUniversity of Cincinnati College of Medicine, Cincinnati, OH, USA.
Jonathan RosandCenter for Genomic Medicine, MGH, Boston, MA, USA.
Guillaume ParePopulation Health Research Institute, McMaster University, Hamilton, Ontario, Canada.
Jemma C HopewellClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Danish SaleheenDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-6193-020X
Kari Stefansson *deCODE genetics/AMGEN Inc., Reykjavik, Iceland.
Bradford B Worrall *Departments of Neurology and Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA.
Steven J Kittner *Department of Neurology, University of Maryland School of Medicine and Baltimore VAMC, Baltimore, MD, USA.
Sudha Seshadri *Framingham Heart Study, Framingham, MA, USA.
Myriam Fornage *Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Hugh S Markus *INSERM U1219 Bordeaux Population Health Research Center, University of Bordeaux, France.
Joanna M M Howson *MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Yoichiro Kamatani *Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.ORCID http://orcid.org/0000-0001-8748-5597
Stephanie Debette *Stroke Research Group, Division of Clinical Neurosciences, University of Cambridge, Cambridge, UK. stephanie.debette@u-bordeaux.fr.
Martin Dichgans *Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany. martin.dichgans@med.uni-muenchen.de.ORCID http://orcid.org/0000-0002-0654-387X

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI LIRETTE, SETH · 2016 to 2025
$38.2M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI MEYER, OANH L · 1991 to 2020
$28.3M
Cardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3M
Risk Factors for Ischemic Stroke in WomenR01HL088521 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REXRODE, KATHRYN M · 2008 to 2025
$9.9M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
CHARGE: Identifying Risk & Protective SNV for AD in ADSP Case-control SampleU01AG049505 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI SESHADRI, SUDHA · 2014 to 2017
$3.0M
British Heart Foundation CH/12/2/29428British Heart Foundation FS/14/55/30806British Heart Foundation RG/13/13/30194British Heart Foundation RG/16/4/32218Intramural NIH HHS Z99 AG999999Medical Research Council MC_UU_12015/1Medical Research Council MR/L003120/1Medical Research Council MR/P013880/1Medical Research Council MR/P02811X/1NCATS NIH HHS UL1 TR001881NHLBI NIH HHS K23 HL114724NHLBI NIH HHS K24 HL105780NHLBI NIH HHS R01 HL088521NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL138423NHLBI NIH HHS U01 HL130114NIA NIH HHS P30 AG010129NIA NIH HHS R01 AG054076NIA NIH HHS U01 AG049505NIDDK NIH HHS P30 DK063491NIGMS NIH HHS U54 GM115428NIH HHS S10 OD020069NINDS NIH HHS R01 NS017950NINDS NIH HHS R01 NS087541
6 · The paper itself

Abstract

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage-disequilibrium-score regression. Several loci exhibited distinct association and pleiotropy patterns for etiological stroke subtypes. Eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets. Stroke risk loci were significantly enriched in drug targets for antithrombotic therapy.

Indexed as

Computational BiologyDatabases, GeneticEpigenesis, GeneticFemaleGene Regulatory NetworksGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansINDEL MutationLinkage DisequilibriumMaleModels, GeneticPolymorphism, Single NucleotideRisk FactorsStroke

Identifiers

PMID29531354
PMCPMC5968830

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.