ReviewHypertension research : official journal of the Japanese Society of Hypertension2018
Arterial stiffness in end-stage renal disease-pathogenesis, clinical epidemiology, and therapeutic potentials.
Review in Hypertension research : official journal of the Japanese Society of Hypertension, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04539418 (Effect of Vitamin K2 Supplementation on Vascular Calcification in Hemodialysis Patients), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Vitamin K2 Supplementation on Vascular Calcification in Hemodialysis Patients: a Controlled Randomized Trial.
Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- A Study on the Neurological Mechanisms of the Impact of Different Dialysis Methods on Brain Structure and Functional Network Dynamic Reorganization in Patients With End-Stage Renal Disease Undergoing Dialysis.Brain and behavior · 2025Trial
- Nutritional Challenges in Hemodialysis: A Perspective from Albania.The Eurasian journal of medicine · 2026Article
- Time-dependent association between progression of arterial stiffness and risk of incident chronic kidney disease: a cohort study in China.Diabetologia · 2026Article
- Do Peritoneal Dialysis Patients with Increased Vascular Stiffness Measured by Pulse Wave Velocity Have Reduced Bone Mineral Density Measured with Dual Energy X-Ray Absorptiometry?Kidney & blood pressure research · 2026Article
- Aortic Pulse Wave Velocity and Extracellular Water Expansion in Hemodialysis Patients.Artificial organs · 2025Article
- Exploring the Interplay Between Kidney Dysfunction and Cardiovascular Disease.Medical sciences (Basel, Switzerland) · 2025Review
- The Association Between Serum TrimethylamineToxins · 2024Article
- Effects of Continuous Positive Airway Pressure Treatment on Vascular Function in a Real-Life Cohort of Elderly Patients with Obstructive Sleep Apnoea Syndrome.Biomedicines · 2024Article
- Correlation of serum Klotho, fetuin-A, and MGP levels with coronary artery calcification in maintenance hemodialysis patients.Clinics (Sao Paulo, Brazil) · 2024Article
- Associations of Glucometabolic Indices with Aortic Stiffness in Patients Undergoing Peritoneal Dialysis with and without Diabetes Mellitus.International journal of molecular sciences · 2023Article
- Number of Teeth and Nutritional Status Parameters Are Related to Intima-Media Thickness in Dalmatian Kidney Transplant Recipients.Journal of personalized medicine · 2022Article
- Fiber connectivity density mapping in end-stage renal disease patients: a preliminary study.Brain imaging and behavior · 2022Article
- A comparative analysis of ambulatory BP profile and arterial stiffness between CAPD and APD.Journal of human hypertension · 2022Article
- Serum biomarkers, skin autofluorescence and other methods. Which parameter better illustrates the relationship between advanced glycation end products and arterial stiffness in the general population?Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Continuous Positive Airway Pressure Improves Renal Function in Obese Patients With Obstructive Sleep Apnea Syndrome.Frontiers in medicine · 2021Article
- Postdialysis blood pressure is a better predictor of mortality than predialysis blood pressure in Japanese hemodialysis patients: the Japan Dialysis Outcomes and Practice Patterns Study.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Snapshot Photoacoustic Topography Through an Ergodic Relay for High-throughput Imaging of Optical Absorption.Nature photonics · 2020Article
- Soluble receptor for advanced glycation end-products independently influences individual age-dependent increase of arterial stiffness.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Article
- Role of Macrophages in the Progression and Regression of Vascular Calcification.Frontiers in pharmacology · 2020Review
- Pharmacologic Therapies for Aortic Stiffness in End-Stage Renal Disease: A Systematic Review and Meta-Analysis.Canadian journal of kidney health and disease · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arterial stiffness is an important risk factor for cardiovascular morbidity and mortality in patients with end-stage renal disease (ESRD). Arterial stiffness aggravates cardiovascular risk via multiple pathways, such as augmentation of aortic systolic pressure, subendocardial hypoperfusion, and excess pulsatile energy transmission from macro- to microcirculation. Pathogenesis of the arteriosclerotic process in ESRD is complex and not yet fully understood. Several factors unique to ESRD, such as mineral metabolism disturbances, vascular calcifications, formation of advanced glycation end-products, and acute and chronic volume overload, are proposed to play a particular role in the progression of arteriosclerosis in ESRD. As these and other mechanistic pathways of arterial stiffening in ESRD are elucidated, there is hope that this knowledge will be translated into novel therapeutic interventions targeting arterial stiffness. In the meantime, blood pressure (BP) lowering via strict volume control and appropriate use of antihypertensive drugs is a fundamental step in reversing accelerated arterial stiffening and modifying the cardiovascular risk profile of ESRD patients. In this article, we review the pathogenesis, clinical epidemiology, and therapies targeting arterial stiffness in ESRD, discussing recent advances and high-priority goals of future research in these important areas.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.