Evidence map›Paper›PMID 29531279›Full record

ArticleScientific reports2018

Genome-wide association analysis identifies new candidate risk loci for familial intracranial aneurysm in the French-Canadian population.

Sirui Zhou, Ziv Gan-Or, Amirthagowri Ambalavanan, Dongbing Lai, Pingxing Xie, Cynthia V Bourassa, Stephanie Strong, Jay P Ross, Alexandre Dionne-Laporte, Dan Spiegelman and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 2 countries.

Sirui ZhouMontreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada.
Ziv Gan-OrMontreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada.
Amirthagowri AmbalavananMontreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada.
Dongbing LaiDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Pingxing XieMontreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada.
Cynthia V BourassaMontreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada.
Stephanie StrongMontreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada.
Jay P RossMontreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada.
Alexandre Dionne-LaporteMontreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada.
Dan SpiegelmanMontreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada.
Nicolas DupréFaculty of Medicine, Université Laval, Quebec, QC, Canada.
Tatiana M ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Lan XiongDepartment of Medicine, Faculty of Medicine, Université de Montréal, Montréal, QC, Canada.
Patrick A DionMontreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada.
Guy A RouleauMontreal Neurological Institute and Hospital, McGill University, Montréal, QC, Canada. guy.rouleau@mcgill.ca.
Montreal Neurological Institute and Hospital · CAIndiana University School of MedicineInstitut Universitaire en Santé Mentale de Québec · CAUniversité Laval · CA

Funding

CIHR
6 · The paper itself

Abstract

Intracranial Aneurysm (IA) is a common disease with a worldwide prevalence of 1-3%. In the French-Canadian (FC) population, where there is an important founder effect, the incidence of IA is higher and is frequently seen in families. In this study, we genotyped a cohort of 257 mostly familial FC IA patients and 1,992 FC controls using the Illumina NeuroX SNP-chip. The most strongly associated loci were tested in 34 Inuit IA families and in 32 FC IA patients and 106 FC controls that had been exome sequenced (WES). After imputation, one locus at 3p14.2 (FHIT, rs1554600, p = 4.66 × 10

Indexed as

Genetic LociGenetic Predisposition to DiseaseAcid Anhydride HydrolasesAdultAgedBis(5'-adenosyl)triphosphataseCanadaCohort StudiesExtracellular Matrix ProteinsFemaleFounder EffectGenome-Wide Association StudyGlycoproteinsHumansIntercellular Signaling Peptides and ProteinsIntracranial AneurysmAcid Anhydride HydrolasesBis(5'-adenosyl)triphosphataseCCDC80 protein, humanExtracellular Matrix ProteinsGlycoproteinsIntercellular Signaling Peptides and ProteinsNeoplasm Proteins

Identifiers

PMID29531279
PMCPMC5847615
OpenAlexW2805711476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.