ArticleEndocrine connections2018
Clinical diagnosis of Graves' or non-Graves' hyperthyroidism compared to TSH receptor antibody test.
Article in Endocrine connections, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Effect of Graves' disease on the prognosis of differentiated thyroid carcinoma: a meta-analysis.Endocrine · 2020Pooled it
- Simultaneous immune checkpoint blockade-associated diabetes mellitus and thyrotoxicosis.JCEM case reports · 2026Article
- Evaluation of the analytical and clinical characteristics of the siemens immulite®2000 tsi method for determining thyrotropin receptor antibodies.Journal of medical biochemistry · 2025Article
- Management, biomarkers and prognosis in people developing endocrinopathies associated with immune checkpoint inhibitors.Nature reviews. Endocrinology · 2025Review
- The Free Thyroxine-to-Thyroid Stimulating Hormone Ratio: A Potential Diagnostic Marker for Graves' Disease.International journal of endocrinology and metabolism · 2025Article
- Clinical characteristics and outcomes of patients with TSH-secreting pituitary adenoma and Graves' disease - a case report and systematic review.Thyroid research · 2024Article
- The Use of Tissue-on-Chip Technology to Focus the Search for Extracellular Vesicle miRNA Biomarkers in Thyroid Disease.International journal of molecular sciences · 2023Article
- Autoimmune thyroid status in subclinical thyroid disorders in patients attending a tertiary care center in Nepal: a hospital-based cross-sectional study.BMC endocrine disorders · 2023Article
- Regulatory mechanisms of microRNAs in endocrine disorders and their therapeutic potential.Frontiers in genetics · 2023Review
- Alemtuzumab-Induced Autoimmune Thyroid Dysfunction.Cureus · 2022Article
- Article
- Evaluation of analytic and clinical performance of two immunoassays for detecting thyroid-stimulating receptor antibody in the diagnosis of Graves' disease.Journal of clinical laboratory analysis · 2021Article
- Graves' disease in a patient with Down syndrome: a shift from hyperthyroidism to hypothyroidism.BMJ case reports · 2021Article
- Graves' disease.Nature reviews. Disease primers · 2020Review
- [Progress in the research of negative feedback effect of thyroglobulin].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2019Review
- EFFECT OF THE C-TERMINUS OF TSHR ON T4 AND TRAB EXPRESSION IN BALB/C MICE.Acta endocrinologica (Bucharest, Romania : 2005)Article
- Thyrotropin receptor antibody immunoassays may not be reliable in confirming diagnosis of Painless Thyroiditis.Acta endocrinologica (Bucharest, Romania : 2005)Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTSH receptor antibody (TRAb) is considered the gold standard diagnostic test for the autoimmunity of Graves' disease (GD), which is commonly diagnosed clinically.
aimTo evaluate the true positive (sensitivity) and true negative (specificity) rates of clinical diagnosis of GD or non-GD hyperthyroidism compared to the TRAb test.
settingUniversity teaching hospital in North West England.
participantsPatients in the Endocrinology service who had a TRAb measurement between December 2009 and October 2015.
methodsElectronic patient records were studied retrospectively for a pre-TRAb clinical diagnosis of GD or non-GD hyperthyroidism. We examined descriptive statistics and binary classification tests; Fisher exact test was used to analyse contingency tables.
resultsWe identified 316 patients with a mean age of 45 (range, 17-89) years; 247 (78%) were women. Compared to the TRAb result, clinical diagnosis had a sensitivity of 88%, specificity 66%, positive predictive value 72%, negative predictive value 84%, false negative rate 12%, false positive rate 34%, positive likelihood ratio 2.6 and negative likelihood ratio 0.2 (
conclusionsClinicians were liable to both over- and under-diagnose GD. The TRAb test can help reduce the number of incorrect or unknown diagnoses in the initial clinical assessment of patients presenting with hyperthyroidism.
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