ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2018
Resource-driven changes to host population stability alter the evolution of virulence and transmission.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- On the diverse and opposing effects of nutrition on pathogen virulence.Proceedings. Biological sciences · 2019Pooled it
- On the Cause and Consequences of Coinfection: A General Mechanistic Framework of Within-Host Parasite Competition.Ecology letters · 2025Review
- Immunological feedback loops generate parasite persistence thresholds that explain variation in infection duration.Proceedings. Biological sciences · 2024Article
- The impact of sterility-mortality tolerance and recovery-transmission trade-offs on host-parasite coevolution.Proceedings. Biological sciences · 2024Article
- Resource asynchrony and landscape homogenization as drivers of virulence evolution: The case of a directly transmitted disease in a social host.Ecology and evolution · 2024Article
- How do fluctuating ecological dynamics impact the evolution of hosts and parasites?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Infection burdens and virulence under heat stress: ecological and evolutionary considerations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Stochasticity directs adaptive evolution toward nonequilibrium evolutionary attractors.Ecology · 2023Article
- Genetic slippage after sex maintains diversity for parasite resistance in a natural host population.Science advances · 2022Article
- Host phenology regulates parasite-host demographic cycles and eco-evolutionary feedbacks.Ecology and evolution · 2022Article
- A rapid phenotype change in the pathogen Perkinsus marinus was associated with a historically significant marine disease emergence in the eastern oyster.Scientific reports · 2021Article
- Movement can mediate temporal mismatches between resource availability and biological events in host-pathogen interactions.Ecology and evolution · 2021Article
- Transient disease dynamics across ecological scales.Theoretical ecology · 2021Article
- Untapped potential: The utility of drylands for testing eco-evolutionary relationships between hosts and parasites.International journal for parasitology. Parasites and wildlife · 2020Article
- Within-host priority effects and epidemic timing determine outbreak severity in co-infected populations.Proceedings. Biological sciences · 2020Article
- Resource fluctuations inhibit the reproduction and virulence of the human parasiteProceedings. Biological sciences · 2020Article
- Anthropogenic resource subsidies and host-parasite dynamics in wildlife.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Food for contagion: synthesis and future directions for studying host-parasite responses to resource shifts in anthropogenic environments.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Resource-driven changes to host population stability alter the evolution of virulence and transmission.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
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2 authors.
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Abstract
What drives the evolution of parasite life-history traits? Recent studies suggest that linking within- and between-host processes can provide key insight into both disease dynamics and parasite evolution. Still, it remains difficult to understand how to pinpoint the critical factors connecting these cross-scale feedbacks, particularly under non-equilibrium conditions; many natural host populations inherently fluctuate and parasites themselves can strongly alter the stability of host populations. Here, we develop a general model framework that mechanistically links resources to parasite evolution across a gradient of stable and unstable conditions. First, we dynamically link resources and between-host processes (host density, stability, transmission) to virulence evolution, using a 'non-nested' model. Then, we consider a 'nested' model where population-level processes (transmission and virulence) depend on resource-driven changes to individual-level (within-host) processes (energetics, immune function, parasite production). Contrary to 'non-nested' model predictions, the 'nested' model reveals complex effects of host population dynamics on parasite evolution, including regions of evolutionary bistability; evolution can push parasites towards strongly or weakly stabilizing strategies. This bistability results from dynamic feedbacks between resource-driven changes to host density, host immune function and parasite production. Together, these results highlight how cross-scale feedbacks can provide key insights into the structuring role of parasites and parasite evolution.This article is part of the theme issue 'Anthropogenic resource subsidies and host-parasite dynamics in wildlife'.
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