Evidence map›Paper›PMID 29531077›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Jia-Yue Zhang, Minxian Wang, Lei Tian, Giulio Genovese, Paul Yan, James G Wilson, Ravi Thadhani, Amy K Mottl, Gerald B Appel, Alexander G Bick and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.

  1. Pooled it
  2. Update on APOL1 and chronic kidney diseases in children.Pediatric nephrology (Berlin, Germany) · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Multiethnic prevalence of theClinical kidney journal · 2025
    Article
  10. The roles of the ubiquitin-proteasome system in renal disease.International journal of medical sciences · 2025
    Review
  11. Article
  12. Review
  13. A Small Molecule Agonist of Krüppel-Like Factor 15 in Proteinuric Kidney Disease.Journal of the American Society of Nephrology : JASN · 2024
    Article
  14. Defining Risk in APOL1-Associated Kidney Disease: The Story is Evolving!American journal of kidney diseases : the official journal of the National Kidney Foundation · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Novel Therapies inKidney international reports · 2023
    Review
  20. Apolipoprotein L1 (APOL1) cation current in HEK-293 cells and in human podocytes.Pflugers Archiv : European journal of physiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 1 country.

Jia-Yue ZhangDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Minxian WangDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215; minxian@broadinstitute.org mpollak@bidmc.harvard.edu.
Lei TianStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.
Giulio GenoveseStanley Center for Psychiatric Research, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142.
Paul YanDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216.
Ravi ThadhaniDepartment of Medicine, Massachusetts General Hospital, Boston, MA 02114.
Amy K MottlUniversity of North Carolina Kidney Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599.
Gerald B AppelCenter for Glomerular Diseases, Columbia University Medical Center, New York, NY 10032.
Alexander G BickDepartment of Medicine, Massachusetts General Hospital, Boston, MA 02114.ORCID 0000-0001-5824-9595
Matthew G SampsonDepartment of Pediatrics, University of Michigan School of Medicine, Ann Arbor, MI 48109.
Seth L AlperDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.
David J FriedmanDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Martin R PollakDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215; minxian@broadinstitute.org mpollak@bidmc.harvard.edu.
Beth Israel Deaconess Medical Center · USBroad Institute · USCardiovascular Institute of the South · USColumbia University Irving Medical Center · USMassachusetts General Hospital · USUniversity of Michigan · USUniversity of Mississippi Medical Center · USUniversity of North Carolina at Chapel Hill · US

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GRANGER, JOEY P. · 2016 to 2025
$38.2M
The Genetic Basis of FSGSR01DK054931 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI POLLAK, MARTIN R. · 1999 to 2017
$6.2M
APOL1 variants: Understanding the basis of disparities in rates of kidney diseaseR01MD007092 · NIMHD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FRIEDMAN, DAVID J, POLLAK, MARTIN R. · 2012 to 2021
$4.3M
APOL1 - associated nephropathy from human-derived, intrarenal perspectiveR01DK108805 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MATTHEW Gordon SAMPSON, Simone Sanna-Cherchi · 2016 to 2026
$3.4M
Molecular Mechanism of APOL1 Associated Kidney DiseaseR01MD007898 · NIMHD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ALPER, SETH LEO, POLLAK, MARTIN R. · 2013 to 2017
$2.2M
Molecular Genetics of Inherited Focal GlomerulosclerosisR56DK054931 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI POLLAK, MARTIN R. · 2008 to 2008
$54k
NHLBI NIH HHS HHSN268201300046CNHLBI NIH HHS HHSN268201300047CNHLBI NIH HHS HHSN268201300048CNHLBI NIH HHS HHSN268201300049CNHLBI NIH HHS HHSN268201300050CNIDDK NIH HHS R01 DK054931NIDDK NIH HHS R01 DK108805NIDDK NIH HHS R56 DK054931NIGMS NIH HHS U54 GM115428NIMHD NIH HHS R01 MD007092NIMHD NIH HHS R01 MD007898
6 · The paper itself

Abstract

People of recent African ancestry develop kidney disease at much higher rates than most other groups. Two specific coding variants in the Apolipoprotein-L1 gene

Indexed as

Polymorphism, Single NucleotideAllelesApolipoprotein L1Black or African AmericanGenetic Predisposition to DiseaseGenotypeGlomerulosclerosis, Focal SegmentalHumansRisk FactorsUbiquitinsAPOL1 protein, humanApolipoprotein L1UBD protein, humanUbiquitinsAPOL1FAT10FSGSkidneyUBD

Identifiers

PMID29531077
PMCPMC5879665
OpenAlexW2790786579

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.