Evidence map›Paper›PMID 29531072›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Correlation analysis framework for localization-based superresolution microscopy.

Joerg Schnitzbauer, Yina Wang, Shijie Zhao, Matthew Bakalar, Tulip Nuwal, Baohui Chen, Bo Huang

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Electrochemical Dye Switching Assisted Spectral Demixing and 3D STORM Imaging.Angewandte Chemie (International ed. in English) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joerg SchnitzbauerDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143.
Yina WangDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143.
Shijie ZhaoSchool of Life Sciences, Peking University, Beijing 100871, China.
Matthew BakalarUC Berkeley-UCSF Joint Graduate Group in Bioengineering, University of California, Berkeley, CA 94720.
Tulip NuwalDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143.
Baohui ChenDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143.
Bo HuangDepartment of Pharmaceutical Chemistry, University of California, San Francisco, CA 94143; bo.huang@ucsf.edu.ORCID 0000-0003-1704-4141

Funding

Solving macromolecular complex architecture in situ by super-resolution microscopDP2OD008479 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, BO · 2011 to 2011
$2.3M
NIH HHS DP2 OD008479
6 · The paper itself

Abstract

Superresolution images reconstructed from single-molecule localizations can reveal cellular structures close to the macromolecular scale and are now being used routinely in many biomedical research applications. However, because of their coordinate-based representation, a widely applicable and unified analysis platform that can extract a quantitative description and biophysical parameters from these images is yet to be established. Here, we propose a conceptual framework for correlation analysis of coordinate-based superresolution images using distance histograms. We demonstrate the application of this concept in multiple scenarios, including image alignment, tracking of diffusing molecules, as well as for quantification of colocalization, showing its superior performance over existing approaches.

Indexed as

AnimalsCell LineDNADrosophilaDrosophila ProteinsFluorescent DyesGolgi ApparatusGolgi Matrix ProteinsImage Processing, Computer-AssistedMembrane ProteinsMicroscopy, FluorescenceMolecular ImagingSpatio-Temporal AnalysisDNADrosophila ProteinsFluorescent DyesGolgi Matrix ProteinsGRASP65 protein, DrosophilaMembrane Proteinsdiffusionimage analysissingle-molecule imagingsuperresolution microscopy

Identifiers

PMID29531072
PMCPMC5879654

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.