ArticleProceedings of the National Academy of Sciences of the United States of America2018
Detection of amyloid fibrils in Parkinson's disease using plasmonic chirality.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 304 citations in OpenAlex.
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- Nanomaterial strategies for mitigating protein misfolding and neuroinflammation in neurodegenerative diseases.Zoological research · 2026Review
- Quantum-elevated chiral discrimination for biomolecules.Science advances · 2026Article
- Unlocking the Translational Potential of Nanophotonic Biosensors: Perspectives on Application-Guided Design.ACS photonics · 2025Review
- Tunable Plasmonic Circular Dichroism of Hierarchical Chiral Assemblies.Chemistry of materials : a publication of the American Chemical Society · 2025Article
- Concavity-enhanced chiral self-assembly of anisotropic nanoparticles toward strong chiroptical activity.Nature communications · 2025Article
- Quantitative diagnosis of amyloid without Congo red staining using polarized light microscopy.Biomedical optics express · 2025Article
- Harnessing the Power of Plasmonics forACS photonics · 2025Review
- Enantioselective synthesis of chiroplasmonic helicoidal nanoparticles by nanoconfinement in chiral dielectric shells.Nature communications · 2025Article
- Optical chirality of all dielectric q-BIC metasurface with symmetry breaking.Nanophotonics (Berlin, Germany) · 2025Article
- Recent Advances in Chiral Gold Nanomaterials: From Synthesis to Applications.Molecules (Basel, Switzerland) · 2025Review
- Optical biosensors for diagnosing neurodegenerative diseases.Npj biosensing · 2025Review
- Controllable Synthesis of Three-Dimensional Chiral Au Nanoflowers Induced by Cysteine with Excellent Biocompatible Properties.Nanomaterials (Basel, Switzerland) · 2024Article
- Plasmonic nanoparticle sensors: current progress, challenges, and future prospects.Nanoscale horizons · 2024Review
- Quantitative 3D structural analysis of small colloidal assemblies under native conditions by liquid-cell fast electron tomography.Nature communications · 2024Article
- Tau- and α-synuclein-targeted gold nanoparticles: applications, opportunities, and future outlooks in the diagnosis and therapy of neurodegenerative diseases.Journal of nanobiotechnology · 2024Review
- Nanotechnology's frontier in combatting infectious and inflammatory diseases: prevention and treatment.Signal transduction and targeted therapy · 2024Review
- Gold Nanoparticles in Parkinson's Disease Therapy: A Focus on Plant-Based Green Synthesis.Cureus · 2024Review
- Multicomponent chiral plasmonic hybrid nanomaterials: recent advances in synthesis and applications.Nanoscale advances · 2024Review
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amyloid fibrils, which are closely associated with various neurodegenerative diseases, are the final products in many protein aggregation pathways. The identification of fibrils at low concentration is, therefore, pivotal in disease diagnosis and development of therapeutic strategies. We report a methodology for the specific identification of amyloid fibrils using chiroptical effects in plasmonic nanoparticles. The formation of amyloid fibrils based on α-synuclein was probed using gold nanorods, which showed no apparent interaction with monomeric proteins but effective adsorption onto fibril structures via noncovalent interactions. The amyloid structure drives a helical nanorod arrangement, resulting in intense optical activity at the surface plasmon resonance wavelengths. This sensing technique was successfully applied to human brain homogenates of patients affected by Parkinson's disease, wherein protein fibrils related to the disease were identified through chiral signals from Au nanorods in the visible and near IR, whereas healthy brain samples did not exhibit any meaningful optical activity. The technique was additionally extended to the specific detection of infectious amyloids formed by prion proteins, thereby confirming the wide potential of the technique. The intense chiral response driven by strong dipolar coupling in helical Au nanorod arrangements allowed us to detect amyloid fibrils down to nanomolar concentrations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.