Evidence map›Paper›PMID 29531045›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Complex electrophysiological remodeling in postinfarction ischemic heart failure.

Bence Hegyi, Julie Bossuyt, Leigh G Griffiths, Rafael Shimkunas, Zana Coulibaly, Zhong Jian, Kristin N Grimsrud, Claus S Sondergaard, Kenneth S Ginsburg, Nipavan Chiamvimonvat and 10 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 99 citations in OpenAlex.

  1. Trial
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  3. Synergistic antiarrhythmic mechanism of IJournal of translational medicine · 2025
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  4. Article
  5. Myocardial-alternation index (MMI) is correlated with soluble suppression of tumorigenecity-2 (sST2) in patients with ischemic cardiomyopathy.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025
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  11. Atomistic mechanisms of the regulation of small-conductance CaProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Review
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  14. Automatic measurement of short-term variability of repolarization to indicate ventricular arrhythmias in a porcine model of cardiac ischaemia.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 3 countries.

Bence HegyiDepartment of Pharmacology, University of California, Davis, CA 95616.ORCID 0000-0003-3113-221X
Julie BossuytDepartment of Pharmacology, University of California, Davis, CA 95616.
Leigh G GriffithsDepartment of Veterinary Medicine and Epidemiology, University of California, Davis, CA 95616.
Rafael ShimkunasDepartment of Pharmacology, University of California, Davis, CA 95616.
Zana CoulibalyDepartment of Pharmacology, University of California, Davis, CA 95616.
Zhong JianDepartment of Pharmacology, University of California, Davis, CA 95616.
Kristin N GrimsrudDepartment of Surgery, University of California, Davis, Sacramento, CA 95817.
Claus S SondergaardDepartment of Surgery, University of California, Davis, Sacramento, CA 95817.
Kenneth S GinsburgDepartment of Pharmacology, University of California, Davis, CA 95616.
Nipavan ChiamvimonvatDepartment of Pharmacology, University of California, Davis, CA 95616.
Luiz BelardinelliDepartment of Clinical Research, Gilead Sciences, Inc., Foster City, CA 94404.
András VarróDepartment of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary.
Julius G PappDepartment of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, H-6720 Szeged, Hungary.
Piero PolleselloCritical Care Proprietary Products, Orion Pharma, FI-02200 Espoo, Finland.
Jouko LevijokiCritical Care Proprietary Products, Orion Pharma, FI-02200 Espoo, Finland.
Leighton T IzuDepartment of Pharmacology, University of California, Davis, CA 95616.
W Douglas BoydDepartment of Surgery, University of California, Davis, Sacramento, CA 95817.
Tamás BányászDepartment of Pharmacology, University of California, Davis, CA 95616.
Donald M BersDepartment of Pharmacology, University of California, Davis, CA 95616.
Ye Chen-IzuDepartment of Pharmacology, University of California, Davis, CA 95616; ychenizu@ucdavis.edu.
University of California, Davis · USOrion Corporation (Finland) · FIUniversity of Szeged · HUGilead Sciences (United States) · USMayo Clinic · USUniversity of Debrecen · HUVA Northern California Health Care System · US

Funding

Program AdministrationP01HL080101 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M · 2006 to 2015
$23.4M
Pathophysiological Regulation of Cardiac Myocyte RyR ChannelR01HL092097 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Donald M Bers, Robyn T Rebbeck · 2010 to 2026
$9.3M
Functional Interactions of Cardiac Ion ChannelsR01HL085844 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2007 to 2025
$7.3M
Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
Translational Study of Cardiac DysfunctionR01HL085727 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN, SIRISH, PADMINI · 2008 to 2022
$5.7M
Phospholemman and Na-Pump Function in Cardiac MyocytesR01HL081562 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M · 2005 to 2018
$5.3M
IONIC CONTROL OF CARDIAC MUSCLE CONTRACTION: EC COUPLINGR01HL030077 · NHLBI · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI BERS, DONALD M · 1986 to 2018
$3.8M
Multi-scale Systems Model of Murine Heart FailureR01HL105242 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BERS, DONALD M, MCCULLOCH, ANDREW D. · 2012 to 2016
$3.5M
Decoding the enigma of cardiac amplificationR01HL137228 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2017 to 2020
$2.2M
AKAP-dependent regulation of Cardiac SR Ca handlingR01HL133832 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERS, DONALD M · 2017 to 2020
$2.0M
Novel Cell-in-Gel System for Mechanotransduction Study at the Single Cell LevelR01HL123526 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEN-IZU, YE · 2015 to 2018
$1.8M
Sarcomere Length Shortening and the Destabilization of the Ca2+ Control System inR01HL090880 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI IZU, LEIGHTON T. · 2009 to 2012
$1.5M
BLRD VA I01 BX000576CSRD VA I01 CX001490NHLBI NIH HHS P01 HL080101NHLBI NIH HHS R01 HL030077NHLBI NIH HHS R01 HL081562NHLBI NIH HHS R01 HL085727NHLBI NIH HHS R01 HL085844NHLBI NIH HHS R01 HL090880NHLBI NIH HHS R01 HL092097NHLBI NIH HHS R01 HL105242NHLBI NIH HHS R01 HL123526NHLBI NIH HHS R01 HL133832NHLBI NIH HHS R01 HL137228NHLBI NIH HHS T32 HL086350
6 · The paper itself

Abstract

Heart failure (HF) following myocardial infarction (MI) is associated with high incidence of cardiac arrhythmias. Development of therapeutic strategy requires detailed understanding of electrophysiological remodeling. However, changes of ionic currents in ischemic HF remain incompletely understood, especially in translational large-animal models. Here, we systematically measure the major ionic currents in ventricular myocytes from the infarct border and remote zones in a porcine model of post-MI HF. We recorded eight ionic currents during the cell's action potential (AP) under physiologically relevant conditions using

Indexed as

Electrophysiological PhenomenaAction PotentialsAnimalsArrhythmias, CardiacCalciumCells, CulturedHeart FailureMyocardial InfarctionMyocytes, CardiacSwineCalciumaction potentialelectrophysiologyionic currentsischemic heart failuremyocardial infarction

Identifiers

PMID29531045
PMCPMC5879679
OpenAlexW2791834647

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.