ArticleBioscience reports2018
The effect of earthworm extract on promoting skin wound healing.
Article in Bioscience reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
- Lumbrokinase-containing gelatin nanofibers with multiple bioactivities for effective skin wound healing.Materials today. Bio · 2025Article
- Effects of Earthworm (Heliyon · 2025Article
- Mucus-derived biomaterial dressings: a novel approach to accelerate wound healing.Theranostics · 2025Review
- The Promoting Effect of Animal Bioactive Proteins and Peptide Components on Wound Healing: A Review.International journal of molecular sciences · 2024Review
- Enhancing the wound healing potential using earthworm clitellum factors and elucidating its molecular mechanism in an in-vitro and earthworm model.Scientific reports · 2024Article
- Pharmacological effects of bioactive agents in earthworm extract: A comprehensive review.Animal models and experimental medicine · 2024Review
- Decoding the mechanism of earthworm extract against wounds: an integrated metabolomics and network pharmacology study.Molecular diversity · 2024Article
- The Effects ofAdvanced biomedical research · 2024Article
- Promoted Skin Wound Healing by Tail-AmputatedACS omega · 2023Article
- Antibiofilm Potential of Coelomic Fluid and Paste of EarthwormMicroorganisms · 2023Article
- Lumbrokinase, a Fibrinolytic Enzyme, Prevents Intra-Abdominal Adhesion by Inhibiting the Migrative and Adhesive Activities of Fibroblast via Attenuation of the AP-1/ICAM-1 Signaling Pathway.BioMed research international · 2023Article
- A Novel Peptide fromToxins · 2022Article
- Beneficial Effects of Oleosomes Fused with Human Fibroblast Growth Factor 1 on Wound Healing via the Promotion of Angiogenesis.International journal of molecular sciences · 2022Article
- A Comprehensive Review of Natural Compounds for Wound Healing: Targeting Bioactivity Perspective.International journal of molecular sciences · 2022Review
- Reproductive Injury in Male Rats from Acrylamide Toxicity and Potential Protection by Earthworm Methanolic Extract.Animals : an open access journal from MDPI · 2022Article
- Physicochemical Properties and Antibacterial Activity of Gellan Gum Incorporating Zinc Oxide/Carbon Nanotubes Bionanocomposite Film for Wound Healing.Bioinorganic chemistry and applications · 2022Article
- In Vitro and In Vivo Activity of 14-Molecules (Basel, Switzerland) · 2021Article
- Study on the Effect and Mechanism of Antibacterial Adhesive Hydrogel on Wound Healing.Computational and mathematical methods in medicine · 2021Observational
- Effect of Earthworm on Wound Healing: A Systematic Review and Meta-Analysis.Frontiers in pharmacology · 2021Review
- Acute Wound Healing Potential of Marine Worm,Evidence-based complementary and alternative medicine : eCAM · 2020Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic nonhealing wounds pose a significant challenge to healthcare system because of its tremendous utilization of resources and time to heal. It has a well-deserved reputation for reducing the quality of life for those affected and represent a substantial economic burden to the healthcare system overall. Earthworms are used as a traditional Chinese medicine, and have been applied pharmacologically and clinically since a long time in China. However, there is paucity in data regarding its wound healing effects. Therefore, we investigated the effect of earthworm extract (EE) on skin wound healing process. The obtained data showed that EE has healing effects on local wound of mice. It decreased the wound healing time and reduced the ill-effects of inflammation as determined by macroscopic, histopathologic, hematologic, and immunohistochemistry parameters. The potential mechanism could be accelerated hydroxyproline and transforming growth factor-β secretion-thus increasing the synthesis of collagen, promoting blood capillary, and fibroblast proliferation. It could accelerate the removal of necrotic tissue and foreign bodies by speeding up the generation of interleukin-6, white blood cells, and platelets. It thus enhances immunity, reduces the risk of infection, and promotes wound healing. All in all, the obtained data demonstrated that EE improves quality of healing and could be used as a propitious wound healing agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.