Evidence map›Paper›PMID 29531012›Full record

ArticleGenetics2018

MIB-1 Is Required for Spermatogenesis and Facilitates LIN-12 and GLP-1 Activity in

Miriam Ratliff, Katherine L Hill-Harfe, Elizabeth J Gleason, Huiping Ling, Tim L Kroft, Steven W L'Hernault

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. UtilizingJournal of developmental biology · 2025
    Review
  4. Article
  5. Article
  6. E3 ubiquitin ligase Mindbomb 1 facilitates nuclear delivery of adenovirus genomes.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  7. Sperm Differentiation: The Role of Trafficking of Proteins.International journal of molecular sciences · 2020
    Review
  8. Biology of theGenetics · 2019
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Miriam RatliffDepartment of Biology, Emory University, Atlanta, Georgia 30322.
Katherine L Hill-HarfeDepartment of Biology, Emory University, Atlanta, Georgia 30322.
Elizabeth J GleasonDepartment of Biology, Emory University, Atlanta, Georgia 30322.
Huiping LingDepartment of Biology, Emory University, Atlanta, Georgia 30322.
Tim L KroftDepartment of Biology, Emory University, Atlanta, Georgia 30322.
Steven W L'HernaultDepartment of Biology, Emory University, Atlanta, Georgia 30322 bioslh@emory.edu.ORCID 0000-0002-1597-1008
Emory University · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Secretory Vesicle Function During Spermatogenesis & Fertilization in C. elegansR01GM082932 · NIGMS · EMORY UNIVERSITY · PI L'HERNAULT, STEVEN W. · 2007 to 2010
$1.2M
GENETICS OF CAENORHABDITIS ELEGANS SPERM MORPHOGENESISR01GM040697 · NIGMS · EMORY UNIVERSITY · PI L'HERNAULT, STEVEN W. · 1995 to 2003
$951k
An Izumo-Like Protein in C. elegans and its Role during FertilizationR21HD066577 · NICHD · EMORY UNIVERSITY · PI L'HERNAULT, STEVEN W. · 2011 to 2012
$426k
NICHD NIH HHS R21 HD066577NIGMS NIH HHS R01 GM040697NIGMS NIH HHS R01 GM082932NIH HHS P40 OD010440
6 · The paper itself

Abstract

Covalent attachment of ubiquitin to substrate proteins changes their function or marks them for proteolysis, and the specificity of ubiquitin attachment is mediated by the numerous E3 ligases encoded by animals. Mind Bomb is an essential E3 ligase during Notch pathway signaling in insects and vertebrates. While

Indexed as

AllelesAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsGene Expression Regulation, DevelopmentalGlucagon-Like Peptide 1Loss of Function MutationMutationPhenotypeReceptors, NotchSignal TransductionSpermatogenesisUbiquitin-Protein LigasesCaenorhabditis elegans ProteinsGlucagon-Like Peptide 1Lin-12 protein, C elegansmib-1 protein, C elegansReceptors, NotchUbiquitin-Protein LigasesC. elegansMind BombNotch signalingspermatogenesisubiquitin E3 ligase

Identifiers

PMID29531012
PMCPMC5935030
OpenAlexW2793469422

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.