Evidence map›Paper›PMID 29530928›Full record

ArticleGenome research2018

Nucleosomes and DNA methylation shape meiotic DSB frequency in

Kyuha Choi, Xiaohui Zhao, Andrew J Tock, Christophe Lambing, Charles J Underwood, Thomas J Hardcastle, Heïdi Serra, Juhyun Kim, Hyun Seob Cho, Jaeil Kim and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 235 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Breeding better crops: lessons from the homologous recombination pathway.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
    Review
  7. Article
  8. Review
  9. Why recombination hotspots?PLoS genetics · 2026
    Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Review
  17. Histone variant H2A.W7 represses meiotic crossover formation inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. The histone variant H2A.W restricts heterochromatic crossovers inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Review
  20. Review

82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 3 countries.

Kyuha ChoiDepartment of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, United Kingdom.
Xiaohui ZhaoDepartment of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, United Kingdom.
Andrew J TockDepartment of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, United Kingdom.
Christophe LambingDepartment of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, United Kingdom.
Charles J UnderwoodDepartment of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, United Kingdom.
Thomas J HardcastleDepartment of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, United Kingdom.
Heïdi SerraDepartment of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, United Kingdom.
Juhyun KimDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Republic of Korea.
Hyun Seob ChoDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Republic of Korea.
Jaeil KimDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Republic of Korea.
Piotr A ZiolkowskiDepartment of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, United Kingdom.
Nataliya E YelinaDepartment of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, United Kingdom.
Ildoo HwangDepartment of Life Sciences, Pohang University of Science and Technology, Pohang, Gyeongbuk, 37673, Republic of Korea.
Robert A MartienssenHoward Hughes Medical Institute-Gordon and Betty Moore Foundation, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Ian R HendersonDepartment of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, United Kingdom.
University of Cambridge · GBPohang University of Science and Technology · KRHoward Hughes Medical Institute · US

Funding

Biotechnology and Biological Sciences Research Council BB/K007882/1Biotechnology and Biological Sciences Research Council BB/L006847/1Biotechnology and Biological Sciences Research Council BB/M004937/1Biotechnology and Biological Sciences Research Council BB/N007557/1
6 · The paper itself

Abstract

Meiotic recombination initiates from DNA double-strand breaks (DSBs) generated by SPO11 topoisomerase-like complexes. Meiotic DSB frequency varies extensively along eukaryotic chromosomes, with hotspots controlled by chromatin and DNA sequence. To map meiotic DSBs throughout a plant genome, we purified and sequenced

Indexed as

ArabidopsisArabidopsis ProteinsChromosomes, FungalDNA Breaks, Double-StrandedDNA MethylationDNA Transposable ElementsEpigenesis, GeneticMeiosisMeiotic Recombination Protein SPO11NucleosomesRegulatory Sequences, Nucleic AcidArabidopsis ProteinsDNA Transposable ElementsMeiotic Recombination Protein SPO11NucleosomesSpo11-1 protein, Arabidopsis

Identifiers

PMID29530928
PMCPMC5880243
OpenAlexW2952945559

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.