Evidence map›Paper›PMID 29530927›Full record

ArticleGenome research2018

Epigenetic activation of meiotic recombination near

Charles J Underwood, Kyuha Choi, Christophe Lambing, Xiaohui Zhao, Heïdi Serra, Filipe Borges, Joe Simorowski, Evan Ernst, Yannick Jacob, Ian R Henderson and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Genome research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 220 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Why recombination hotspots?PLoS genetics · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Histone variant H2A.W7 represses meiotic crossover formation inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Article
  20. The histone variant H2A.W restricts heterochromatic crossovers inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Charles J UnderwoodHoward Hughes Medical Institute, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Kyuha ChoiDepartment of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, United Kingdom.
Christophe LambingDepartment of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, United Kingdom.
Xiaohui ZhaoDepartment of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, United Kingdom.
Heïdi SerraDepartment of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, United Kingdom.
Filipe BorgesHoward Hughes Medical Institute, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Joe SimorowskiHoward Hughes Medical Institute, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Evan ErnstHoward Hughes Medical Institute, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Yannick JacobHoward Hughes Medical Institute, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Ian R HendersonDepartment of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, United Kingdom.
Robert A MartienssenHoward Hughes Medical Institute, Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
Howard Hughes Medical Institute · USUniversity of Cambridge · GB

Funding

RNAi, Histone Modification and the DDB1/CPSF-Like Complex Rik1R01GM076396 · NIGMS · COLD SPRING HARBOR LABORATORY · PI MARTIENSSEN, ROBERT A · 2007 to 2020
$4.9M
Transposons, RNA Interference and HeterochromatinR01GM067014 · NIGMS · COLD SPRING HARBOR LABORATORY · PI MARTIENSSEN, ROBERT A · 2003 to 2016
$4.1M
Biotechnology and Biological Sciences Research Council BB/K007882/1Biotechnology and Biological Sciences Research Council BB/M004937/1Biotechnology and Biological Sciences Research Council BB/N007557/1Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM067014NIGMS NIH HHS R01 GM076396
6 · The paper itself

Abstract

Eukaryotic centromeres contain the kinetochore, which connects chromosomes to the spindle allowing segregation. During meiosis, centromeres are suppressed for inter-homolog crossover, as recombination in these regions can cause chromosome missegregation and aneuploidy. Plant centromeres are surrounded by transposon-dense pericentromeric heterochromatin that is epigenetically silenced by histone 3 lysine 9 dimethylation (H3K9me2), and DNA methylation in CG and non-CG sequence contexts. However, the role of these chromatin modifications in control of meiotic recombination in the pericentromeres is not fully understood. Here, we show that disruption of

Indexed as

ArabidopsisArabidopsis ProteinsCentromereDNA Breaks, Double-StrandedDNA (Cytosine-5-)-MethyltransferasesDNA MethylationEpigenesis, GeneticGenome, PlantHeterochromatinHistone-Lysine N-MethyltransferaseHistonesHomologous RecombinationMeiosisMethyltransferasesArabidopsis ProteinsDNA (Cytosine-5-)-MethyltransferasesHeterochromatinHistone-Lysine N-MethyltransferaseHistonesMethyltransferasesSUVH4 protein, ArabidopsisSUVH5 protein, ArabidopsisSUVH6 protein, Arabidopsis

Identifiers

PMID29530927
PMCPMC5880242
OpenAlexW2949990911

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.