Evidence map›Paper›PMID 29530881›Full record

ArticleDevelopment (Cambridge, England)2018

Imprinted gene dysregulation in a

Jennifer M SanMiguel, Lara K Abramowitz, Marisa S Bartolomei

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. DysregulatedeLife · 2022
    Article
  10. Article
  11. Article
  12. Genetic Studies on Mammalian DNA Methyltransferases.Advances in experimental medicine and biology · 2022
    Article
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jennifer M SanMiguelUniversity of Pennsylvania, Perelman School of Medicine, Department of Cell and Developmental Biology, SCTR 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.ORCID 0000-0002-5882-0752
Lara K AbramowitzUniversity of Pennsylvania, Perelman School of Medicine, Department of Cell and Developmental Biology, SCTR 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA.
Marisa S BartolomeiUniversity of Pennsylvania, Perelman School of Medicine, Department of Cell and Developmental Biology, SCTR 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA bartolom@pennmedicine.upenn.edu.ORCID 0000-0001-9410-5222
University of Pennsylvania · USNational Institutes of Health · US

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Rebecca A Simmons · 2006 to 2026
$35.3M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008216 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, DOUGLAS J · 1987 to 2023
$8.3M
Sequences controlling H19 Gene ImprintingR37GM051279 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 2011 to 2020
$3.9M
Exploring the molecular mechanisms of TET1 in genomic imprintingF31GM119271 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI SANMIGUEL, JENNIFER MYERS · 2016 to 2017
$85k
NIEHS NIH HHS P30 ES013508NIGMS NIH HHS F31 GM119271NIGMS NIH HHS R37 GM051279NIGMS NIH HHS T32 GM008216
6 · The paper itself

Abstract

Imprinted genes are expressed from one parental allele and regulated by differential DNA methylation at imprinting control regions (ICRs). ICRs are reprogrammed in the germline through erasure and re-establishment of DNA methylation. Although much is known about DNA methylation establishment, DNA demethylation is less well understood. Recently, the Ten-Eleven Translocation proteins (TET1-3) have been shown to initiate DNA demethylation, with

Indexed as

AnimalsDNA-Binding ProteinsDNA MethylationEpigenomicsFemaleGenomic ImprintingGerm CellsMaleMiceMice, Inbred C57BLMice, Inbred ICRMice, KnockoutProto-Oncogene ProteinsReal-Time Polymerase Chain ReactionDNA-Binding ProteinsProto-Oncogene ProteinsTET1 protein, mouseAllele-specific expressionDNA methylationEpigenetic reprogrammingGenomic imprintingImprinting control region (ICR)Methylcytosine dioxygenaseMouseTet1

Identifiers

PMID29530881
PMCPMC5963867
OpenAlexW2789697085

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.