ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2018
Risk of stroke in patients with dengue fever: a population-based cohort study.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Viral Infections and Risk of Cardiovascular Disease: Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2025Pooled it
- Review
- Epidemiology and risk factors of stroke in the Americas: a comprehensive narrative literature review.Lancet regional health. Americas · 2026Review
- Sex differences in dengue-related neurological complications: insights from the 2023 Taiwan outbreak.Brain communications · 2026Article
- Dengue and severe dengue.Clinical microbiology reviews · 2025Review
- Long-term Sequelae Following Dengue Infection vs SARS-CoV-2 Infection in a Pediatric Population: A Retrospective Cohort Study.Open forum infectious diseases · 2025Article
- Stroke from Infection.Cerebrovascular diseases extra · 2025Review
- Review
- Frailty in Older Adults with Dengue Fever.Medicina (Kaunas, Lithuania) · 2024Article
- Stroke in Asia.Cerebrovascular diseases extra · 2024Review
- Ischemic Stroke During Dengue Infection: A Report of 2 Cases.The American journal of case reports · 2023Article
- Major acute cardiovascular events after dengue infection-A population-based observational study.PLoS neglected tropical diseases · 2022Observational
- Case Report: Dengue Hemorrhagic Fever with Ischemic Stroke.The American journal of tropical medicine and hygiene · 2021Article
- Viral Infection and Cardiovascular Disease: Implications for the Molecular Basis of COVID-19 Pathogenesis.International journal of molecular sciences · 2021Review
- Neurological disease in adults with Zika and chikungunya virus infection in Northeast Brazil: a prospective observational study.The Lancet. Neurology · 2020Observational
- Higher incidence of stroke in patients with dengue fever: Spurious association or causal link?CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2019Article
- The authors respond to "Higher incidence of stroke in patients with dengue fever: Spurious association or causal link?"CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2019Article
- The authors respond to "Is there a real increased risk of stroke in patients with dengue fever?"CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Article
- Is there a real increased risk of stroke in patients with dengue fever?CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStroke is a severe neurologic complication of dengue fever, described in only a few case reports. The incidence and risk factors for stroke in patients with dengue remain unclear. We conducted a population-based retrospective cohort study to investigate the risk of stroke in patients with dengue.
methodsUsing data from the Taiwan National Health Insurance Research Database, we included a total of 13 787 patients with dengue newly diagnosed between 2000 and 2012. The control cohort consisted of patients who did not have dengue, matched 1:1 by demographic characteristics and stroke-related comorbidities. We calculated the cumulative incidences and hazard ratios (HRs) of stroke in both cohorts using Kaplan-Meier curves and Cox proportional hazards regression.
resultsThe overall incidence rate of stroke was 5.33 per 1000 person-years in the dengue cohort and 3.72 per 1000 person-years in the control cohort, with an adjusted HR of 1.16 (95% confidence interval [CI] 1.01-1.32). The risk of stroke among patients with dengue was highest in the first 2 months after diagnosis (25.53 per 1000 person-years, adjusted HR 2.49, 95% CI 1.48-4.18).
interpretationDengue fever was associated with an increased risk of stroke in the first few months after diagnosis. The effect of dengue on stroke may be acute rather than chronic.
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