Evidence map›Paper›PMID 29530853›Full record

ArticleAntimicrobial agents and chemotherapy2018

Tapering Courses of Oral Vancomycin Induce Persistent Disruption of the Microbiota That Provide Colonization Resistance to Clostridium difficile and Vancomycin-Resistant Enterococci in Mice.

Myreen E Tomas, Thriveen S C Mana, Brigid M Wilson, Michelle M Nerandzic, Samira Joussef-Piña, Miguel E Quiñones-Mateu, Curtis J Donskey

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. Navigating recurrentAntimicrobial stewardship & healthcare epidemiology : ASHE · 2025
    Article
  3. Article
  4. Biofilm Formation ofMicroorganisms · 2023
    Review
  5. Article
  6. Efficacy of prolonged tapered and pulsed vancomycin regimen on recurrentJournal of pharmaceutical health care and sciences · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Myreen E TomasGeriatric Research Education and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Thriveen S C ManaResearch Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Brigid M WilsonGeriatric Research Education and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Michelle M NerandzicResearch Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA.
Samira Joussef-PiñaDepartments of Pathology and Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Miguel E Quiñones-MateuDepartments of Pathology and Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Curtis J DonskeyGeriatric Research Education and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA curtis.donskey@va.gov.
Geriatric Research Education and Clinical Center · USUniversity School · USCase Western Reserve University · US

Funding

WG3: HIV, Co-infections and Co-morbiditiesP30AI036219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI Sharon L. Hillier, JONATHAN KARN · 1994 to 2026
$50.0M
NIAID NIH HHS P30 AI036219
6 · The paper itself

Abstract

Vancomycin taper regimens are commonly used for the treatment of recurrent

Indexed as

AnimalsAnti-Bacterial AgentsClostridioides difficileClostridium InfectionsFemaleFidaxomicinMiceMicrobiotaVancomycin ResistanceVancomycin-Resistant EnterococciAnti-Bacterial AgentsFidaxomicincolonization resistanceoral vancomycin

Identifiers

PMID29530853
PMCPMC5923165
OpenAlexW2792003290

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.