Evidence map›Paper›PMID 29530719›Full record

ArticleBone2018

Rescue of a cherubism bone marrow stromal culture phenotype by reducing TGFβ signaling.

Yaling Liu, Tulika Sharma, I-Ping Chen, Ernst Reichenberger, Yasuyoshi Ueki, Yumna Arif, Daniel Parisi, Peter Maye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yaling LiuDepartment of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, United States.
Tulika SharmaDepartment of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, United States.
I-Ping ChenDepartment of Oral Health and Diagnostic Sciences, School of Dental Medicine, Farmington CT, United States.
Ernst ReichenbergerDepartment of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, United States.
Yasuyoshi UekiDepartment of Oral and Craniofacial Sciences, School of Dentistry, University of Missouri, Kansas City, MO, United States.
Yumna ArifDepartment of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, United States.
Daniel ParisiDepartment of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, United States.
Peter MayeDepartment of Reconstructive Sciences, School of Dental Medicine, University of Connecticut Health, Farmington, CT, United States. Electronic address: pmaye@uchc.edu.
UConn Health · USUniversity of Missouri–Kansas City · US

Funding

Mechanism of Bone Resorption in PeriodontitisR01DE025870 · NIDCR · UNIVERSITY OF MISSOURI KANSAS CITY · PI UEKI, YASUYOSHI · 2016 to 2020
$2.1M
Cherubism and Transforming Growth Factor Beta SignalingR21DE025933 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MAYE, PETER · 2016 to 2017
$433k
Osteolytic Conversion of Inflammatory MacrophagesR21AR070953 · NIAMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI UEKI, YASUYOSHI · 2016 to 2017
$368k
NIAMS NIH HHS R21 AR070953NIDCR NIH HHS R01 DE025870NIDCR NIH HHS R21 DE025933
6 · The paper itself

Abstract

We utilized a bone marrow stromal culture system to investigate changes in TGFβ signaling in a mouse model for cherubism (Sh3bp2

Indexed as

Adaptor Proteins, Signal TransducingAnimalsBenzodioxolesBone Marrow CellsBone ResorptionCell DifferentiationCells, CulturedCherubismDisease Models, AnimalFemurGenetic MarkersImidazolesMembrane ProteinsMiceMolecular Targeted TherapyOsteoblasts2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochlorideAdaptor Proteins, Signal TransducingBambi protein, mouseBenzodioxolesGenetic MarkersImidazolesMembrane ProteinsPyridinesRANK LigandSh3bp2 protein, mouseTnfsf11 protein, mouseTransforming Growth Factor betaBoneCherubismOsteoblastOsteoclastStromal cellTGFβ

Identifiers

PMID29530719
PMCPMC5924722
OpenAlexW2793214213

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.