Evidence map›Paper›PMID 29530713›Full record

ArticleExperimental neurology2018

DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats.

Peter M Grace, Xiaohui Wang, Keith A Strand, Michael V Baratta, Yingning Zhang, Erika L Galer, Hang Yin, Steven F Maier, Linda R Watkins

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 103 citations in OpenAlex.

  1. The neuroimmune-glutamate hypothesis of addiction.Neuroscience and biobehavioral reviews · 2026
    Review
  2. Glial cells in neuropathic pain.Physiological reviews · 2026
    Review
  3. Sex-specific role of microglia in ΔNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
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  9. Review
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  15. Review
  16. Gene therapy for chronic pain management.Cell reports. Medicine · 2024
    Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Peter M GraceDepartment of Psychology and Neuroscience, The Center for Neuroscience, University of Colorado, Boulder, CO, USA; Discipline of Pharmacology, Adelaide Medical School, University of Adelaide, Adelaide, SA, Australia. Electronic address: pgrace@mdanderson.org.
Xiaohui WangDepartment of Psychology and Neuroscience, The Center for Neuroscience, University of Colorado, Boulder, CO, USA; Department of Chemistry and Biochemistry, BioFrontiers Institute, The Center for Neuroscience, University of Colorado, Boulder, CO, USA.
Keith A StrandDepartment of Psychology and Neuroscience, The Center for Neuroscience, University of Colorado, Boulder, CO, USA.
Michael V BarattaDepartment of Psychology and Neuroscience, The Center for Neuroscience, University of Colorado, Boulder, CO, USA.
Yingning ZhangDepartment of Psychology and Neuroscience, The Center for Neuroscience, University of Colorado, Boulder, CO, USA.
Erika L GalerDepartment of Psychology and Neuroscience, The Center for Neuroscience, University of Colorado, Boulder, CO, USA.
Hang YinDepartment of Chemistry and Biochemistry, BioFrontiers Institute, The Center for Neuroscience, University of Colorado, Boulder, CO, USA.
Steven F MaierDepartment of Psychology and Neuroscience, The Center for Neuroscience, University of Colorado, Boulder, CO, USA.
Linda R WatkinsDepartment of Psychology and Neuroscience, The Center for Neuroscience, University of Colorado, Boulder, CO, USA.
University of Colorado Boulder · US

Funding

Preventing Transition of Acute-to-Chronic Neuropathic Pain: Models, Mechanisms &R01DE021966 · NIDCR · UNIVERSITY OF COLORADO · PI BARTH, DANIEL S., FLESHNER, MONIKA · 2011 to 2015
$2.0M
Exploring the Potential of Glia for Regulating Clinically Relevant Opiod ActionsR01DA023132 · NIDA · UNIVERSITY OF COLORADO · PI WATKINS, LINDA · 2008 to 2012
$1.9M
Exogenous Chemical Probes of TLR-Mediated NeuroinflammationR01GM101279 · NIGMS · UNIVERSITY OF COLORADO · PI YIN, HANG HUBERT · 2013 to 2017
$1.4M
NIDA NIH HHS R01 DA023132NIDCR NIH HHS R01 DE021966NIGMS NIH HHS R01 GM101279
6 · The paper itself

Abstract

The absence of selective pharmacological tools is a major barrier to the in vivo study of microglia. To address this issue, we developed a G

Indexed as

AnimalsClozapineDesigner DrugsDisease Models, AnimalInflammationMaleMicrogliaNeuralgiaRatsRats, Sprague-DawleyReceptors, G-Protein-CoupledSignal TransductionSpinal CordTransfectionClozapineclozapine N-oxideDesigner DrugsReceptors, G-Protein-CoupledAAVAllodyniaChemogeneticsCNOGene therapyIntrathecalMinocyclineNeuropathic pain

Identifiers

PMID29530713
PMCPMC5916033
OpenAlexW2792576326

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.