ArticleExperimental neurology2018
Mapping and neuromodulation of lower urinary tract function using spinal cord stimulation in female rats.
Article in Experimental neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Trial
- Impact of Electrical Spinal Cord Stimulation on Lower Urinary Tract Dysfunction in Mice With Spinal Cord Injury.International neurourology journal · 2026Article
- A Pilot Feasibility Trial of Multi-Program Epidural Spinal Cord Stimulation for Bladder Function Recovery in Chronic Spinal Cord Injury.Journal of clinical medicine · 2026Article
- Article
- Functional mapping of the lower urinary tract by epidural electrical stimulation of the spinal cord in decerebrated cat model.Scientific reports · 2024Article
- Stochastic electrical stimulation of the thoracic or cervical regions with surface electrodes facilitates swallow in rats.Frontiers in neurology · 2024Article
- Mid-lumbar (L3) epidural stimulation effects on bladder and external urethral sphincter in non-injured and chronically transected urethane-anesthetized rats.Scientific reports · 2023Article
- Detrusor underactivity is associated with metabolic syndrome in aged primates.Scientific reports · 2023Article
- High-density spinal cord stimulation selectively activates lower urinary tract nerves.Journal of neural engineering · 2022Article
- Targeting bladder function with network-specific epidural stimulation after chronic spinal cord injury.Scientific reports · 2022Article
- Noninvasive spinal neuromodulation mitigates symptoms of idiopathic overactive bladder.Bioelectronic medicine · 2022Article
- Spinal interneurons of the lower urinary tract circuits.Autonomic neuroscience : basic & clinical · 2021Review
- Bladder and bowel responses to lumbosacral epidural stimulation in uninjured and transected anesthetized rats.Scientific reports · 2021Article
- A shape-adjusted ellipse approach corrects for varied axonal dispersion angles and myelination in primate nerve roots.Scientific reports · 2021Article
- Site-Specific Neuromodulation of Detrusor and External Urethral Sphincter by Epidural Spinal Cord Stimulation.Frontiers in systems neuroscience · 2020Article
- Verification and Defined Dosage of Sodium Pentobarbital for a Urodynamic Study in the Possibility of Survival Experiments in Female Rat.BioMed research international · 2020Article
- Spinal cord stimulation ameliorates detrusor over-activity and visceromotor pain responses in rats with cystitis.Neurourology and urodynamics · 2019Article
- Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Spinal cord epidural stimulation (SCS) represents a form of neuromodulation for the management of spasticity and pain. This technology has recently emerged as a new approach for potentially augmenting locomotion and voiding function in humans and rodents after spinal cord injury. However, the effect of SCS on micturition has not been studied extensively. Here, SCS was first applied as a direct stimulus onto individual segmental levels of the lumbar spinal cord in rats to map evoked external urethral sphincter (EUS) electromyography activity and SCS-induced voiding contractions. SCS of L2-3 inhibited EUS tonic activity, and SCS on L3 (L3/SCS) inhibited EUS tonic activity and elicited EUS bursting. In contrast, SCS of L1 and L4-6 evoked EUS tonic contractions, which resembled the urethral guarding reflex during bladder storage. Next, the effects of a bilateral pelvic nerve crush (PNC) injury on urodynamic function were examined at 14 days post-operatively. The PNC injury resulted in decreased voiding efficiency and maximum intravesical pressure, whereas the post-voiding residual volume was increased, suggestive of an underactive bladder. Finally, L3/SCS was performed to induce a voiding contraction and enable voiding in rats with a PNC injury. Voiding efficiency was significantly increased, and the residual volume was decreased by L3/SCS in rats after the PNC injury. We conclude that L3/SCS may be used to induce micturition reflexes in a partially filled bladder, reduce urethral resistance, and augment bladder emptying after PNC injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.