ArticleJournal of Ayurveda and integrative medicine
Neuropharmacological evaluation on four traditional herbs used as nervine tonic and commonly available as Shankhpushpi in India.
Article in Journal of Ayurveda and integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Herbal Therapeutics for Alzheimer's Disease: Ancient Indian Medicine System from the Modern Viewpoint.Current neuropharmacology · 2023Pooled it
- Effects of aerobic exercise and dietary flavonoids on cognition: a systematic review and meta-analysis.Frontiers in physiology · 2023Pooled it
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- Pharmacological Activity of Scopoletin: Deciphering the Potential of Coumarins in Cognitive Dysfunction.Current drug research reviews · 2026Review
- Exploring the neuropharmacological properties of scopoletin-richAmerican journal of translational research · 2024Article
- Biochemical analysis of methanolic extract fromBioinformation · 2023Article
- Therapeutic roles of plants for 15 hypothesised causal bases of Alzheimer's disease.Natural products and bioprospecting · 2022Article
- Protective Mechanisms of Nootropic Herb Shankhpushpi (Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Ayurvedic Herbal Therapies: A Review of Treatment and Management of Dementia.Current Alzheimer research · 2022Review
- Evidence-based complementary and alternative medicine bioinformatics approach through network pharmacology and molecular docking to determine the molecular mechanisms of Erjing pill in Alzheimer's disease.Experimental and therapeutic medicine · 2021Article
- Complete chloroplast genome of the medicinal plantPhysiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Genome Characterization, Comparison and Phylogenetic Analysis of Complete Mitochondrial Genome ofLife (Basel, Switzerland) · 2021Article
- Evaluation of Phytochemical, Antioxidant, and Memory-Enhancing Activity ofTheScientificWorldJournal · 2021Article
- Indian Medicinal Herbs and Formulations for Alzheimer's Disease, from Traditional Knowledge to Scientific Assessment.Brain sciences · 2020Review
- Enhanced accumulation of reduced glutathione by Scopoletin improves survivability of dopaminergic neurons in Parkinson's model.Cell death & disease · 2020Article
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4 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundShankhpushpi is an Ayurvedic drug, widely used for its actions on the central nervous system, especially to improve intellect and boost memory. Four botanicals viz. Canscora decussata Schult. (CD), Clitorea ternatea Linn. (CT), Convolvulus pluricaulis Choisy. (CP) and Evolvulus alsinoides Linn. (EA) are considered as sources of Shankhpushpi by Indian practitioners on the basis of their morphological descriptions given in ancient texts.
objectiveThe present study was undertaken to evaluate the neuropharmacological effect of four herbs commonly identified as source of Shankhpushpi. MATERIALS AND
methodsMethanol extracts of all four varieties were tested and evaluated in vitro and in vivo for their neuropharmacological effects. Experiments such as protection against β-amyloid induced neurotoxicity on brain cell line (Neuro 2A), antioxidant potential, AchE (acetylcholinesterase enzyme) inhibition, and 5-LOX (lipoxygenase) enzyme inhibition were conducted for in vitro evaluation. For in vivo evaluation, scopolamine (0.3 mg/kg i.p.) induced memory retrieval using pole climbing apparatus and Morris water maze were performed in rat models.
resultsIt was found that protective effects of EA and CD against β-amyloid induced neurotoxicity in Neuro 2A cells were significantly higher than CT and CP. EA proved to be superior than other varieties on the basis of antioxidant activity, AchE inhibitory and LOX inhibitory activities. The preventive activity of EA on scopolamine induced memory retrieval in pole climbing and Morris water maze task in rats was found to be higher than that of CD, CT and CP.
conclusionEA has remarkable neuropharmacological effect as compared to other three varieties of Shankhpushpi. This effect may be attributed due to the presence of steroids (stigmasterol and betulinic acid), coumarins (scopoletin) and flavonoids (β-carotene and chlorogenic acid). Hence it can be used as a promising lead in development and management of neuronal disorders including Alzheimer's disease.
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