Evidence map›Paper›PMID 29530094›Full record

ArticleBiology of sex differences2018

The impact of biological sex on the response to noise and otoprotective therapies against acoustic injury in mice.

Béatrice Milon, Sunayana Mitra, Yang Song, Zachary Margulies, Ryan Casserly, Virginia Drake, Jessica A Mong, Didier A Depireux, Ronna Hertzano

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology of sex differences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 103 citations in OpenAlex.

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  8. Aging in the Primary Auditory Cortex.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Review
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Béatrice MilonDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Maryland, 16 South Eutaw Street, Suite 500, Baltimore, MD, 21201, USA.
Sunayana MitraDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Maryland, 16 South Eutaw Street, Suite 500, Baltimore, MD, 21201, USA.
Yang SongInstitute for Genome Science, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Zachary MarguliesDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Maryland, 16 South Eutaw Street, Suite 500, Baltimore, MD, 21201, USA.
Ryan CasserlyDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Maryland, 16 South Eutaw Street, Suite 500, Baltimore, MD, 21201, USA.
Virginia DrakeDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Maryland, 16 South Eutaw Street, Suite 500, Baltimore, MD, 21201, USA.
Jessica A MongDepartment of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, 21201, USA.
Didier A DepireuxDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Maryland, 16 South Eutaw Street, Suite 500, Baltimore, MD, 21201, USA.
Ronna HertzanoDepartment of Otorhinolaryngology - Head and Neck Surgery, University of Maryland, 16 South Eutaw Street, Suite 500, Baltimore, MD, 21201, USA. rhertzano@som.umaryland.edu.
University of Maryland, Baltimore · US

Funding

AUTOSOMAL DOMINANT NONSYNDROMIC HEARING LOSSR01DC003544 · NIDCD · UNIVERSITY OF IOWA · PI SMITH, RICHARD J.H. · 1998 to 2017
$7.8M
Cell Type Specific Transcriptional Cascades in Inner Ear DevelopmentR01DC013817 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI HERTZANO, RONNA · 2015 to 2022
$3.6M
Cell Type Specific Transcriptional Cascades in Inner Ear DevelopmentU01DC013817 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI AHMED, ZUBAIR M. · 2023 to 2025
$1.6M
A Zeiss Duo Confocal Microscope for Shared Imaging FacilityS10RR024548 · NCRR · UNIVERSITY OF MARYLAND BALTIMORE · PI BLANPIED, THOMAS A · 2008 to 2008
$500k
NCRR NIH HHS S10 RR024548NIDCD NIH HHS R01 DC003544NIDCD NIH HHS R01 DC013817NIDCD NIH HHS RO1DC013817NIDCD NIH HHS RO1DC03544NIDCD NIH HHS U01 DC013817
6 · The paper itself

Abstract

backgroundNoise-induced hearing loss (NIHL) is the most prevalent form of acquired hearing loss and affects about 40 million US adults. Among the suggested therapeutics tested in rodents, suberoylanilide hydroxamic acid (SAHA) has been shown to be otoprotective from NIHL; however, these results were limited to male mice.

methodsHere we tested the effect of SAHA on the hearing of 10-week-old B6CBAF1/J mice of both sexes, which were exposed to 2 h of octave-band noise (101 dB SPL centered at 11.3 kHz). Hearing was assessed by measuring auditory brainstem responses (ABR) at 8, 16, 24, and 32 kHz, 1 week before, as well as at 24 h and 15-21 days following exposure (baseline, compound threshold shift (CTS) and permanent threshold shift (PTS), respectively), followed by histologic analyses.

resultsWe found significant differences in the CTS and PTS of the control (vehicle injected) mice to noise, where females had a significantly smaller CTS at 16 and 24 kHz (p < 0.0001) and PTS at 16, 24, and 32 kHz (16 and 24 kHz p < 0.001, 32 kHz p < 0.01). This sexual dimorphic effect could not be explained by a differential loss of sensory cells or synapses but was reflected in the amplitude and amplitude progression of wave I of the ABR, which correlates with outer hair cell (OHC) function. Finally, the frequency of the protective effect of SAHA differed significantly between males (PTS, 24 kHz, p = 0.002) and females (PTS, 16 kHz, p = 0.003), and the magnitude of the protection was smaller in females than in males. Importantly, the magnitude of the protection by SAHA was smaller than the effect of sex as a biological factor in the vehicle-injected mice.

conclusionsThese results indicate that female mice are significantly protected from NIHL in comparison to males and that therapeutics for NIHL may have a different effect in males and females. The data highlight the importance of analyzing NIHL experiments from males and females, separately. Finally, these data also raise the possibility of effectors in the estrogen signaling pathway as novel therapeutics for NIHL.

Indexed as

Sex CharacteristicsAnimalsEvoked Potentials, Auditory, Brain StemFemaleHearing Loss, Noise-InducedMaleMiceNoiseProtective AgentsVorinostatProtective AgentsVorinostatABRB6CBAF1/J miceInner earNoise-induced hearing lossSAHASex differences

Identifiers

PMID29530094
PMCPMC5848513
OpenAlexW2800244464

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.